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      Corticotropin Releasing Factor (CRF) Immunoreactivity in Hypothalamic and Extrahypothalamic Nuclei of Sheep Brain

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          Abstract

          Insheep, 26 brain areas of 62 investigated contained corticotropin releasing factor (CRF)-like immunoreactivity in concentrations higher than 0.5 ng CRF/mg protein. Most of the CRF in the brain was in the hypothalamus. The highest level of CRF in the sheep brain was in the median eminence, almost two orders of magnitude higher than anywhere else. All of the hypothalamic nuclei had measureable amounts of CRF. A number of extrahypothalamic regions such as amygdala, hippocampus, claustrum, cingulate cortex, habenula and certain lower brainstem nuclei had CRF but generally in very low concentrations.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1983
          1983
          27 March 2008
          : 37
          : 4
          : 302-305
          Affiliations
          aLaboratory of Cell Biology, National Institute of Mental Health, Bethesda, Md.; bPeptide Biology Laboratory, The Salk Institute, La Jolla, Calif., USA
          Article
          123564 Neuroendocrinology 1983;37:302–305
          10.1159/000123564
          6605489
          © 1983 S. Karger AG, Basel

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          Page count
          Pages: 4
          Categories
          Original Paper

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