Corticotropin Releasing Factor (CRF) Immunoreactivity in Hypothalamic and Extrahypothalamic Nuclei of Sheep Brain

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Abstract

Insheep, 26 brain areas of 62 investigated contained corticotropin releasing factor (CRF)-like immunoreactivity in concentrations higher than 0.5 ng CRF/mg protein. Most of the CRF in the brain was in the hypothalamus. The highest level of CRF in the sheep brain was in the median eminence, almost two orders of magnitude higher than anywhere else. All of the hypothalamic nuclei had measureable amounts of CRF. A number of extrahypothalamic regions such as amygdala, hippocampus, claustrum, cingulate cortex, habenula and certain lower brainstem nuclei had CRF but generally in very low concentrations.

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Author and article information

Journal

Journal ID (publisher-id): NEN

Journal ID (nlm-ta): Neuroendocrinology

Journal ID (doi): 10.1159/issn.0028-3835

Title: Neuroendocrinology

Publisher: S. Karger AG

ISSN (Print): 0028-3835

ISSN (Electronic): 1423-0194

Publication date Subscription-year: 1983

Publication date (Print): 1983

Publication date (Electronic): 27 March 2008

Volume: 37

Issue: 4

Pages: 302-305

Affiliations

^aLaboratory of Cell Biology, National Institute of Mental Health, Bethesda, Md.; ^bPeptide Biology Laboratory, The Salk Institute, La Jolla, Calif., USA

Article

Publisher ID: 123564 Other ID: Neuroendocrinology 1983;37:302–305

DOI: 10.1159/000123564

PubMed ID: 6605489

SO-VID: 23451280-7ef8-4637-8a7f-d032d9700dc6

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 04 March 1983

Date accepted : 27 April 1983

Page count

Pages: 4

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