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      Coexistence of Tyrosine Hydroxylase-Like and Gamma-Aminobutyric Acid-Like Immunoreactivities in Neurons of the Arcuate Nucleus

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          The distribution of glutamic acid decarboxylase(GAD)- and tyrosine hydroxylase(TH)-like immunoreactivities in the hypothalamic arcuate nucleus of the rat was investigated using an indirect immunofluorescence technique. GAD-positive cell bodies were found in the arcuate nucleus, mainly clustered in its dorsomedial parts. A dense terminal plexus was observed in the lateral palisade zone of the median eminence. The apparent overlap of this distribution pattern with that for TH immunoreactivity was studied directly using an elution-restaining procedure. This revealed apparent coexistence of GAD- and TH-like immunoreactivities in a subpopulation of arcuate neurons. The relevance of this finding to the control of anterior pituitary secretion is discussed.

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          Author and article information

          S. Karger AG
          28 March 2008
          : 39
          : 2
          : 189-191
          aDepartment of Anatomy, University of Cambridge, England; bDepartment of Histology, Karolinska Institutet, Stockholm, Sweden; cDepartment of Cell Biology, Baylor College of Medicine, Houston, Tex.; dDepartment of Psychiatry, New York University Medical Center, New York, N.Y., USA
          123977 Neuroendocrinology 1984;39:189–191
          © 1984 S. Karger AG, Basel

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          Pages: 3
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