4
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Loss of Consciousness Is Related to White Matter Injury in Mild Traumatic Brain Injury.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          To study the relation of loss of consciousness (LOC) to white matter integrity after mild traumatic brain injury (mTBI), we acquired diffusion tensor imaging (DTI) at 3 Tesla in 79 participants with mTBI and normal computed tomography (age 18 to 50 years) whom we imaged after a mean post-injury interval of 25.9 h (standard deviation = 12.3) and at 3 months. For comparison, 64 participants with orthopedic injury (OI) underwent DTI at similar intervals. Quantitative tractography was used to measure fractional anisotropy (FA) and mean diffusivity (MD) in the left and right uncinate fasciculus (UF), left and right inferior frontal occipital fasciculus (IFOF), and the genu of the corpus callosum. Generalized estimating equation models assessed the association between LOC and both MD and FA across time after mTBI and compared their DTI metrics with the OI group. LOC was significantly related to MD in UF and IFOF (p values ranged from p < 0.0001 to 0.0270) and to FA in left UF (p = 0.0104) and right UF (p = 0.0404). Between-group differences in MD were significant for left UF, left and right IFOF, and the genu of the corpus callosum on initial DTI, but not at 3 months post-injury, and these differences were specific to the mTBI subgroup with LOC. Groups did not differ in FA at either occasion. Early DTI may provide a biomarker for mTBI with LOC, even in patients whose consciousness recovers by arrival in the emergency department. MD better differentiates mTBI from OI than FA on early DTI, but this is specific to mTBI with LOC. DTI findings support a continuum of white matter injury in early mTBI.

          Related collections

          Author and article information

          Journal
          J. Neurotrauma
          Journal of neurotrauma
          Mary Ann Liebert Inc
          1557-9042
          0897-7151
          Nov 15 2016
          : 33
          : 22
          Affiliations
          [1 ] 1 Michael E. DeBakey VA Medical Center, Baylor College of Medicine , Houston, Texas.
          [2 ] 2 Department of Physical Medicine and Rehabilitation, Baylor College of Medicine , Houston, Texas.
          [3 ] 3 Department of Pediatrics, Baylor College of Medicine , Houston, Texas.
          [4 ] 4 Department of Diagnostic and Interventional Imaging, University of Texas Health Science Center at Houston , Houston, Texas.
          [5 ] 5 University of Texas School of Public Health , Houston, Texas.
          [6 ] 6 Department of Neurosurgery, Baylor College of Medicine , Houston, Texas.
          [7 ] 7 Department of Neurosurgery, Virginia Commonwealth University , Richmond, Virginia.
          [8 ] 8 Department of Radiology, Baylor College of Medicine , Houston, Texas.
          Article
          10.1089/neu.2015.4212
          26801471
          2352e486-6529-44ad-a8e9-f51a9fbc9399
          History

          diffusion tensor imaging,mild traumatic brain injury,loss of consciousness

          Comments

          Comment on this article