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      Expression of Sex Hormone-Binding Globulin and Corticosteroid-Binding Globulin mRNAs in Corpus luteum of Human Subjects

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          Abstract

          To understand the biology of sex steroids in human ovarian corpus luteum, the expression of intracellular sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) mRNAs as a manifestation of intracellular SHBG and CBG expression was determined. The expression of SHBG and CBG mRNAs was detected in all samples analyzed. Luteal SHBG mRNA level showed no significant change during the endometrial secretory phase of the menstrual cycle. On the other hand, luteal CBG mRNA level was significantly higher (p < 0.05) at the mid-secretory phase than that at the early and late secretory phases of the endometrium. These findings suggest that human ovarian corpus luteum synthesizes SHBG and CBG intracellularly, CBG being plausibly involved in the functional life span of corpus luteum.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1997
          1997
          10 December 2008
          : 48
          : 4
          : 191-195
          Affiliations
          Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu, Japan
          Article
          185512 Horm Res 1997;48:191–195
          10.1159/000185512
          9378466
          © 1997 S. Karger AG, Basel

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          Page count
          Pages: 5
          Categories
          Original Paper

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