It is the priority of all health care organizations to promote patient safety. All over the world, numerous people suffer from hospital acquired infections and other adverse events day in and day out. The goal of this study was to verify whether there were any disparities in the way patient safety issues are handled in the United State and the Slovak Republic. This article also explores the types of adverse event and errors and their causes, some universal strategies to minimize safety issues, and some basic steps involved in incident reporting. It was concluded that there was a wide difference in the number of adverse events that are reported in both countries.