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      Pilot study on the efficacy and safety of 0.01 % atropine school children with progressive myopia in Hefei

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      1 , 1
      Chinese Journal of School Health
      Chinese Journal of School Health
      Myopia, Atropine, Intervention studies, Child

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          Abstract

          Objective To investigate the clinical effict of 0.01% atropine for myopia progression in school children, and to provide a reference for probing into an effective methods of preventing myopia among children.

          Methods Thirty children, with a median age of 10 years (range 7-17), were given topical treatment with preservative-free 0.01% atropine eye drops in both eyes before going to bed every night, and the efficacy and safety were analyzed 12 months later. Efficacy was assessed every 6 months. In 10 children, treatment of the second eye was delayed by one day to allow for a controlled safety assessment of side effects such as dilated pupils, hypoplasia and decreased myopia.

          Results In terms of myopia treatment, after 12 months of treatment with 0.01% atropine, it was 0.43 D/year( t = 8.66, P<0.01). In terms of safety, in the 10 children’s treatment of the second eye was delayed by one day, the measurable side effect was the induction of 1 mm pupil dilatation, and there was no other significant abnormalities were observed.

          Conclusion Topical low-dose (0.01%) atropine is safe and effective in school-age children, and it has certain clinical promotion value.

          Abstract

          【摘要】 目的 观察0.01%阿托品滴眼液对进展性近视学龄儿童的治疗情况, 为探寻有效的儿童近视防治措施提供参考。 方法 随机数字表法选取合肥市城区30例进展性近视学龄儿童, 年龄中位数为10(7~ 17)岁, 在每晚睡前双眼使用不含防 腐剂的0.01%阿托品滴眼液进行局部治疗, 12个月后对疗效和安全性进行分析, 每6个月对疗效进行1次评估。其中10 例患者第二只眼睛的治疗延迟1 d, 以便对瞳孔扩大、调节反应、视敏度进行可控的安全性评估。 结果 在近视治疗效果方 面, 0.01%阿托品治疗12个月后, 为0.43 D/年 (t = 8.66, P<0.01)。在安全性方面, 在10例第二只眼睛治疗延迟1 d的患者 中, 可观察到的副作用是诱导了 1 mm的瞳孔扩大;而在调节力、视近敏度及眼压等观察中, 未见明显异常。 结论 0.01% 阿托品滴眼液在治疗学龄儿童近视中安全有效, 具有一定临床推广价值。

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          Author and article information

          Journal
          CJSH
          Chinese Journal of School Health
          Chinese Journal of School Health (China )
          1000-9817
          01 February 2021
          01 February 2021
          : 42
          : 2
          : 173-176
          Affiliations
          [1] 1Department of Ophthalmology of Anhui NO. 2 Provincial People's Hospital, Hefei (230041), China
          Article
          j.cnki.1000-9817.2021.02.004
          10.16835/j.cnki.1000-9817.2021.02.004
          23b3b7a7-3a81-4daa-8415-4f388366dfee
          © 2021 Chinese Journal of School Health

          This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 Unported License (CC BY-NC 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See https://creativecommons.org/licenses/by-nc/4.0/.

          Product
          Self URI (journal-page): http://www.cjsh.org.cn
          Categories
          Journal Article

          Ophthalmology & Optometry,Pediatrics,Nutrition & Dietetics,Clinical Psychology & Psychiatry,Public health
          Intervention studies,Child,Atropine,Myopia

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