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      Migration of monocytes across endothelium and passage through extracellular matrix involve separate molecular domains of PECAM-1

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      The Journal of Experimental Medicine
      The Rockefeller University Press

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          Abstract

          During the inflammatory response, the adhesion molecule PECAM plays a crucial role in transendothelial migration, the passage of leukocytes across endothelium. We report here an additional role for PECAM in the subsequent migration of monocytes through the subendothelial extracellular matrix. PECAM has six immunoglobulin (Ig) superfamily domains. Monoclonal antibodies whose epitopes map to domains 1 and/or 2 selectively block monocyte migration through the endothelial junction, whereas those that map to domain 6 block only the migration through the extracellular matrix, trapping the monocyte between the endothelium and its basal lamina. Therefore, transendothelial migration (diapedesis) and passage through extracellular matrix (interstitial migration) are distinct and separable phases of monocyte emigration. Furthermore, distinct and separate Ig domains of PECAM are involved in mediating these two steps.

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          Author and article information

          Journal
          J Exp Med
          The Journal of Experimental Medicine
          The Rockefeller University Press
          0022-1007
          1540-9538
          1 November 1995
          : 182
          : 5
          : 1337-1343
          Article
          96042131
          10.1084/jem.182.5.1337
          2192210
          7595204
          23b7a3ad-653b-432d-bd74-24fcdf489143
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          Medicine
          Medicine

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