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      Effect of Precirol ATO5 concentration and twin-screw melt granulation temperature on the physical properties of ascorbic acid granules

      1 , 2 , 2 , 1 , 2
      British Journal of Pharmacy
      University of Huddersfield Press

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          Abstract

          The pharmaceuticalindustry has a growing interest in continuous manufacturing, particularly forhigh-volume dosage forms such as solid oral tablets. This is driven by the obviousbenefits such as small footprint, batch size flexibility, the relative simplicityof scale-up and process control. Tablets are the most popular solid dosageform, while batch granulation is one of the most often used technologies intablet manufacturing. Using ascorbic acid as a model, we show the possibility ofproducing granules and tablets with a sustained-release profile using threetechnological operations: mixing, continuous melt-granulation, and tabletting.

          Author and article information

          Journal
          British Journal of Pharmacy
          University of Huddersfield Press
          2058-8356
          April 21 2022
          November 3 2022
          : 7
          : 2
          Affiliations
          [1 ]School of Pharmacy, Queen's University Belfast
          [2 ]Pharmacy, Queen's University Belfast
          Article
          10.5920/bjpharm.1160
          23ba4faf-28fd-4f96-bdf4-698d0675a2cd
          © 2022

          https://creativecommons.org/licenses/by/4.0

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