Increased expression of bronchial epithelial transient receptor potential vanilloid 1 channels in patients with severe asthma.

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Abstract

The airway epithelium is exposed to a range of physical and chemical irritants in the environment that are known to trigger asthma. Transient receptor potential (TRP) cation channels play a central role in sensory responses to noxious physical and chemical stimuli. Recent genetic evidence suggests an involvement of transient receptor potential vanilloid 1 (TRPV1), one member of the vanilloid subfamily of TRP channels, in the pathophysiology of asthma. The functional expression of TRPV1 on airway epithelium has yet to be elucidated.

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Journal

Journal ID (iso-abbrev): J Allergy Clin Immunol

Title: The Journal of allergy and clinical immunology

Publisher: Elsevier BV

ISSN (Electronic): 1097-6825

ISSN (Print): 0091-6749

Publication date (Electronic): Mar 2014

Volume: 133

Issue: 3

Affiliations

[1 ] Centre for Infection and Immunity, Health Sciences Building, Queens University Belfast, Belfast, United Kingdom. Electronic address: l.mcgarvey@qub.ac.uk.

[2 ] Centre for Infection and Immunity, Health Sciences Building, Queens University Belfast, Belfast, United Kingdom.

[3 ] Tissue Pathology, Belfast Health and Social Care Trust, Belfast, United Kingdom.

[4 ] Centre for Vision and Vascular Science, Queens University Belfast, Belfast, United Kingdom.

[5 ] Genentech, South San Francisco, Calif.

[6 ] Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom.

[7 ] Centre for Vision and Vascular Science, Queens University Belfast, Belfast, United Kingdom; Institute of Biology, Taras Shevchenko Kiev National University, Kiev, Ukraine.

[8 ] Department of Respiratory, Otolaryngology and Molecular Medicine, Education and Research Centre, Royal College of Surgeons in Ireland, Dublin, Ireland.

Article

Publisher Item ID: S0091-6749(13)01442-5

DOI: 10.1016/j.jaci.2013.09.016

PubMed ID: 24210884

SO-VID: 23ba83b1-17aa-4b86-8970-a2734ce921ed

History

Keywords: Ion channel,asthma,chemical,cough,exacerbation,irritant,sensory

Data availability:

Keywords: Ion channel, asthma, chemical, cough, exacerbation, irritant, sensory

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