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      Left Ventricular Diastolic Filling Properties in Diabetic Patients during Isometric Exercise

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          Left ventricular diastolic filling properties during isometric handgrip exercise were measured by pulsed Doppler echocardiography in 33 noninsulin-dependent diabetic patients with a normal ejection fraction and 15 control subjects. Diabetic patients were subdivided into two groups according to their resting left ventricular filling pattern (A/E): 18 patients were in group DM-1 (A/E ≤ 1.1) and 15 patients were in group DM-2 (A/E > 1.1). At rest, A/E ratio and A wave were higher, and deceleration half-time was longer in group DM-2 than in normal subjects and group DM-1, but there was no significant difference between normal subjects and group DM-1. The A/E ratio increased significantly in all three groups during isometric handgrip exercise. However, the change in A/E from rest to peak exercise in group DM-1 (0.29 ± 0.20) was significantly greater than in normal subjects (0.09 ± 0.07). These results suggest that diabetes mellitus patients with normal resting left ventricular (LV) filling pattern (group DM-1) had LV diastolic filling abnormalities with isometric handgrip exercise. Doppler echocardiography with isometric handgrip exercise is useful in identifying underlying left ventricular diastolic dysfunction in diabetic patients.

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          Author and article information

          S. Karger AG
          18 November 2008
          : 83
          : 5-6
          : 316-323
          Second Department of Internal Medicine, Kansai Medical University, Osaka, Japan
          175987 Cardiology 1993;83:316–323
          © 1993 S. Karger AG, Basel

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          Page count
          Pages: 8
          General Cardiology


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