Dietary omega-3 fatty acids attenuate myocardial arrhythmogenic factors and propensity of the heart to lethal arrhythmias in a rodent model of human essential hypertension.

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Abstract

Hypertension-induced myocardial remodeling is known to be associated with increased risk for malignant arrhythmias and alterations in electrical coupling protein, connexin-43 (Cx43), may be involved. We investigated whether omega-3 fatty acids intake affects abnormalities of Cx43 as well as protein kinase C (PKC) signaling and myosin heavy chain (MyHC) profile at the early and late stage of hypertension in the context of the heart's susceptibility to ventricular fibrillation and ability to restore sinus rhythm.

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Journal

Journal ID (iso-abbrev): J. Hypertens.

Title: Journal of hypertension

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1473-5598

ISSN (Print): 0263-6352

Publication date (Electronic): Sep 2013

Volume: 31

Issue: 9

Affiliations

[1 ] aInstitute for Heart Research, Slovak Academy of Sciences bFaculty of Medicine, Institute of Physiology, Comenius University cInstitute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Bratislava, Slovakia dFaculty of Science, Department of Physiology, Charles University eInstitute of Physiology, v.v.i., Academy of Sciences of Czech Republic, Prague, Czech Republic fThe National Cardiovascular Institute, Bratislava, Slovakia *Jana Radosinska and Barbara Bacova contributed equally to the writing of the article.

Article

DOI: 10.1097/HJH.0b013e328362215d

PubMed ID: 23719203

SO-VID: 23d2d27a-11de-448e-be5d-c76470dd54e1

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