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      Atypical/Nor98 scrapie: properties of the agent, genetics, and epidemiology.

      Veterinary Research
      Animals, Europe, epidemiology, Prions, genetics, Scrapie, Sheep

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          Abstract

          Atypical/Nor98 scrapie cases in sheep were diagnosed for the first time in Norway in 1998. They are now identified in small ruminants in most European countries and represent an increasingly large proportion of the scrapie cases diagnosed in Europe. Atypical/Nor98 scrapie isolates have shown to be experimentally transmissible into transgenic mice and sheep but the properties of the TSE agent involved, like its biological and biochemical features, are so clearly distinct from the agent involved in classical scrapie that they have provided a challenging diagnostic for many years. No strain diversity has yet been identified among the atypical/Nor98 scrapie sample cases. The genetic predisposition of the sheep affected by atypical/Nor98 scrapie is almost inverted compared to classical scrapie, and the exact origin of this sporadic TSE strain is still speculative, but a spontaneous, non-contagious origin, like sporadic Creutzfeldt-Jakob disease in humans, can not be excluded. Further transmission and epidemiological studies are needed to better address this hypothesis.

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          Author and article information

          Journal
          18187032
          10.1051/vetres:2007056

          Chemistry
          Animals,Europe,epidemiology,Prions,genetics,Scrapie,Sheep
          Chemistry
          Animals, Europe, epidemiology, Prions, genetics, Scrapie, Sheep

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