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      Protective Nature of Platelet-Rich Plasma Against Chondrocyte Death When Combined With Corticosteroids or Local Anesthetics.

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          Abstract

          The use of corticosteroids and local anesthetics to treat osteoarthritis has established benefits, including relief of pain and increased range of motion, but may also have the potential to lead to tissue atrophy or degeneration, specifically on chondrocytes. There is growing evidence that platelet-rich plasma (PRP) has anti-inflammatory characteristics that can limit the cytotoxic effects of corticosteroids and local anesthetics. Hypothesis/Purpose: The purpose of this study was to determine the effects of PRP in chondrocyte cultures when combined with corticosteroids or local anesthetics. The hypothesis of this study was that PRP would (1) dampen the negative effects on chondrocyte viability and (2) improve chondrocyte proliferation seen with corticosteroid or local anesthetic treatment alone.

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          Author and article information

          Journal
          Am J Sports Med
          The American journal of sports medicine
          SAGE Publications
          1552-3365
          0363-5465
          Jan 2017
          : 45
          : 1
          Affiliations
          [1 ] Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, Connecticut, USA.
          [2 ] Center for Sports Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
          Article
          0363546516664161
          10.1177/0363546516664161
          27582279
          23e3880d-dadb-49c9-bedc-51d5d0d189d5
          History

          anesthetic,chondrocyte,corticosteroid,osteoarthritis,platelet-rich plasma

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