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      Clinical outcomes of advanced-stage glassy cell carcinoma of the uterine cervix: a need for reappraisal

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          Abstract

          We performed a retrospective analysis of the clinical features and patient outcomes for advanced-stage glassy cell carcinoma of the uterine cervix. The study was restricted to cases in which the glassy cell features constituted at least 95% of the biopsied specimen. During the study period, 675 patients were diagnosed with primary cervical carcinoma. Five (0.7%) of the 675 patients had cervical glassy cell carcinoma; of these, three were premenopausal, and two were postmenopausal. Abnormal vaginal bleeding was the most frequent presenting symptom. Glassy cell carcinoma presented as a fungating, exophytic, or infiltrative mass. The greatest tumor dimension ranged from 3 to 9 cm. All patients had parametrial extension. Four patients had stage IIB tumors, and one had a stage IIIB tumor. All patients received concurrent chemoradiation therapy. The patient with a stage IIIB tumor died of hypovolemic shock caused by upper gastrointestinal bleeding during radiation therapy. Three patients with stage IIB tumors survived for more than 8 years without tumor recurrence or metastasis. One of these three patients died of pelvic recurrence 10 years after the initial diagnosis. Cervical glassy cell carcinoma has traditionally been considered an aggressive, highly malignant tumor with poor prognosis, but our data suggest that patient survival is not significantly decreased compared with other histological types of cervical carcinoma. It will be necessary to analyze patient outcomes using a larger number of cervical glassy cell carcinoma cases to confirm our findings.

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          Most cited references32

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          Revised FIGO staging for carcinoma of the cervix.

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            Incidence, histology, and response to radiation of mixed carcinomas (adenoacanthomas) of the uterine cervix.

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              Glassy cell carcinoma of the cervix: a systematic review and meta-analysis.

              The purpose of this study is to summarize the data on the incidence, clinical behavior and overall survival of patients with glassy cell cervical carcinoma (GCCC).
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                Author and article information

                Journal
                Oncotarget
                Oncotarget
                Oncotarget
                ImpactJ
                Oncotarget
                Impact Journals LLC
                1949-2553
                29 November 2016
                25 October 2016
                : 7
                : 48
                : 78448-78454
                Affiliations
                1 Department of Pathology, The Catholic University of Korea Incheon St. Mary's Hospital, Incheon, Republic of Korea
                2 Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
                Author notes
                Correspondence to: Hyun-Soo Kim, hyunsookim@ 123456yuhs.org
                Article
                12905
                10.18632/oncotarget.12905
                5346652
                27793022
                23e4dd50-99dd-4467-99f6-ee422e11b609
                Copyright: © 2016 Yoon et al.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 26 September 2016
                : 17 October 2016
                Categories
                Research Paper

                Oncology & Radiotherapy
                cervix,glassy cell carcinoma,concurrent chemoradiation therapy,recurrence,survival

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