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      Critical appraisal of ceftaroline in the management of community-acquired bacterial pneumonia and skin infections

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      Therapeutics and Clinical Risk Management

      Dove Medical Press

      ceftaroline, pneumonia, skin infection

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          Abstract

          Ceftaroline is a novel broad-spectrum cephalosporin β-lactam antibiotic with activity against methicillin-resistant Staphylococcus aureus (MRSA) as well as multidrug-resistant Streptococcus pneumoniae among other routine Gram positive and Gram negative organisms. It has been approved by the US Food and Drug Administration for treatment of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections (ABSSSIs). Ceftaroline is approved for treatment of ABSSSI due to MRSA, however currently there are no data for pneumonia due to MRSA in humans. Herein we review the major clinical trials as well as ceftaroline microbiology, pharmacokinetics, and safety, followed by a look at further directions for investigation of this new agent.

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          Author and article information

          Journal
          Ther Clin Risk Manag
          Ther Clin Risk Manag
          Therapeutics and Clinical Risk Management
          Therapeutics and Clinical Risk Management
          Dove Medical Press
          1176-6336
          1178-203X
          2012
          2012
          26 March 2012
          : 8
          : 149-156
          Affiliations
          Division of Infectious Diseases, The Ohio State University, Columbus, OH, USA
          Author notes
          Correspondence: Stanley I Martin, N1148 Doan Hall, 410 W. 10th Ave, Columbus, OH 43210, USA, Tel +1 614 293 5666, Fax +1 614 293 4556, Email stanley.martin@ 123456osumc.edu
          Article
          tcrm-8-149
          10.2147/TCRM.S17413
          3333463
          22547933
          © 2012 Goodman and Martin, publisher and licensee Dove Medical Press Ltd.

          This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

          Categories
          Review

          Medicine

          pneumonia, skin infection, ceftaroline

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