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      Seeking Polymeric Prodrugs of Norfloxacin. Part 2. Synthesis and Structural Analysis of Polyurethane Conjugates

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          Abstract

          Oligo(ε-caprolactone) and oligolactide were synthesized via ring-opening polymerization of cyclic esters in the presence of creatinine as initiators. Thus obtained oligomers were successfully used in the synthesis of novel polyurethane conjugates of norfloxacin. The structures of the polymers and conjugates were elucidated by means of MALDI-TOF MS, NMR and IR studies.

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          Polymeric systems for controlled drug release.

          Kathryn Uhrich, Scott Cannizzaro, Robert S. Langer … (1999)
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            Recent developments in ring opening polymerization of lactones for biomedical applications.

            Ann-Christine Albertsson, Indra Varma (2003)
            Aliphatic polyesters prepared by ring-opening polymerization of lactones are now used worldwide as bioresorbable devices in surgery (orthopaedic devices, sutures, stents, tissue engineering, and adhesion barriers) and in pharmacology (control drug delivery). This review presents the various methods of the synthesis of polyesters and tailoring the properties by proper control of molecular weight, composition, and architecture so as to meet the stringent requirements of devices in the medical field. The effect of structure on properties and degradation has been discussed. The applications of these polymers in the biomedical field are described in detail.
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              Synthesis methods, chemical structures and phase structures of linear polyurethanes. Properties and applications of linear polyurethanes in polyurethane elastomers, copolymers and ionomers

              P Krol (2007)
              Article 0 comments Cited 102 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Molecules
                Journal ID (iso-abbrev): Molecules
                Journal ID (publisher-id): molecules
                Title: Molecules
                Publisher: Molecular Diversity Preservation International
                ISSN (Electronic): 1420-3049
                Publication date (Electronic): 05 February 2010
                Publication date Collection: February 2010
                Volume: 15
                Issue: 2
                Pages: 842-856
                Affiliations
                Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, ul. Banacha 1, 02-097 Warsaw, Poland; E-Mails: katarzyna.nurzynska@ 123456op.pl (K.N.); waclaw.kolodziejski@ 123456wum.edu.pl (W.K.)
                Author notes
                [* ] Author to whom correspondence should be addressed; E-Mails: marcin.sobczak@ 123456wum.edu.pl ; marcin.sobczak@ 123456wp.pl ; Tel.: +48 22 572 07 55; Fax: +48 22 572 07 84.
                Article
                Publisher ID: molecules-15-00842
                DOI: 10.3390/molecules15020842
                PMC ID: 6263196
                PubMed ID: 20335951
                SO-VID: 23fc6b80-6924-485d-b063-7e1a6bc6501a
                Copyright © © 2010 by the authors;
                License:

                licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license ( http://creativecommons.org/licenses/by/3.0/).

                History
                Date received : 11 January 2010
                Date revision received : 30 January 2010
                Date accepted : 03 February 2010
                Categories
                Subject: Article

                Keywords: aliphatic polyesters,aliphatic polyurethanes,ring-opening polymerization,macromolecular conjugates,prodrugs of norfloxacin
                Data availability:
                Keywords: aliphatic polyesters, aliphatic polyurethanes, ring-opening polymerization, macromolecular conjugates, prodrugs of norfloxacin

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