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      Nanocapsules with excellent biocompatibility and stability in protein solutions

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          Abstract

          Silica nanocapsules stabilized with a reactive surfactant are synthesized to prevent leaching of toxic surfactant. The nanocapsules show a superior stability and biocompatibility compared with nanocapsules prepared with conventional surfactants.

          Abstract

          Silica nanocapsules (SiO 2NCs) are usually prepared with cationic surfactants that are not cytocompatible. Dialysis can be used to remove surfactants but leads to instability of the SiO 2NCs when they are in the presence of proteins or biological media. Herein, SiO 2NCs stabilized with a reactive surfactant are synthesized to prevent leaching upon dialysis. The SiO 2NCs show superior stability and biocompatibility compared with SiO 2NCs prepared with conventional surfactants. The SiO 2NCs can be used in self-healing materials, smart agriculture and biomedical applications.

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          Mesoporous silica nanoparticles: synthesis, biocompatibility and drug delivery.

          Fangqiong Tang, Linlin Li, Dong Chen (2012)
          In the past decade, mesoporous silica nanoparticles (MSNs) have attracted more and more attention for their potential biomedical applications. With their tailored mesoporous structure and high surface area, MSNs as drug delivery systems (DDSs) show significant advantages over traditional drug nanocarriers. In this review, we overview the recent progress in the synthesis of MSNs for drug delivery applications. First, we provide an overview of synthesis strategies for fabricating ordered MSNs and hollow/rattle-type MSNs. Then, the in vitro and in vivo biocompatibility and biotranslocation of MSNs are discussed in relation to their chemophysical properties including particle size, surface properties, shape, and structure. The review also highlights the significant achievements in drug delivery using mesoporous silica nanoparticles and their multifunctional counterparts as drug carriers. In particular, the biological barriers for nano-based targeted cancer therapy and MSN-based targeting strategies are discussed. We conclude with our personal perspectives on the directions in which future work in this field might be focused. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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            Dependence of Nanoparticle Toxicity on Their Physical and Chemical Properties

            Alyona Sukhanova, Svetlana V Bozrova, Pavel Sokolov … (2018)
            Studies on the methods of nanoparticle (NP) synthesis, analysis of their characteristics, and exploration of new fields of their applications are at the forefront of modern nanotechnology. The possibility of engineering water-soluble NPs has paved the way to their use in various basic and applied biomedical researches. At present, NPs are used in diagnosis for imaging of numerous molecular markers of genetic and autoimmune diseases, malignant tumors, and many other disorders. NPs are also used for targeted delivery of drugs to tissues and organs, with controllable parameters of drug release and accumulation. In addition, there are examples of the use of NPs as active components, e.g., photosensitizers in photodynamic therapy and in hyperthermic tumor destruction through NP incorporation and heating. However, a high toxicity of NPs for living organisms is a strong limiting factor that hinders their use in vivo. Current studies on toxic effects of NPs aimed at identifying the targets and mechanisms of their harmful effects are carried out in cell culture models; studies on the patterns of NP transport, accumulation, degradation, and elimination, in animal models. This review systematizes and summarizes available data on how the mechanisms of NP toxicity for living systems are related to their physical and chemical properties.
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              Hollow-structured mesoporous materials: chemical synthesis, functionalization and applications.

              Yongsheng Li, Jianlin Shi (2014)
              Hollow-structured mesoporous materials (HMMs), as a kind of mesoporous material with unique morphology, have been of great interest in the past decade because of the subtle combination of the hollow architecture with the mesoporous nanostructure. Benefitting from the merits of low density, large void space, large specific surface area, and, especially, the good biocompatibility, HMMs present promising application prospects in various fields, such as adsorption and storage, confined catalysis when catalytically active species are incorporated in the core and/or shell, controlled drug release, targeted drug delivery, and simultaneous diagnosis and therapy of cancers when the surface and/or core of the HMMs are functionalized with functional ligands and/or nanoparticles, and so on. In this review, recent progress in the design, synthesis, functionalization, and applications of hollow mesoporous materials are discussed. Two main synthetic strategies, soft-templating and hard-templating routes, are broadly sorted and described in detail. Progress in the main application aspects of HMMs, such as adsorption and storage, catalysis, and biomedicine, are also discussed in detail in this article, in terms of the unique features of the combined large void space in the core and the mesoporous network in the shell. Functionalization of the core and pore/outer surfaces with functional organic groups and/or nanoparticles, and their performance, are summarized in this article. Finally, an outlook of their prospects and challenges in terms of their controlled synthesis and scaled application is presented.
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                Author and article information

                Contributors
                Daniel Crespy: (View ORCID Profile)
                Journal
                Journal ID (publisher-id): BSICCH
                Title: Biomaterials Science
                Abbreviated Title: Biomater. Sci.
                Publisher: Royal Society of Chemistry (RSC)
                ISSN (Print): 2047-4830
                ISSN (Electronic): 2047-4849
                Publication date Created: August 24 2021
                Publication date (Electronic): 2021
                Volume: 9
                Issue: 17
                Pages: 5781-5784
                Affiliations
                [1 ]Department of Materials Science and Engineering, School of Molecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology, 21210 Rayong, Thailand
                [2 ]Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, 25/25 Putthamonthon 4 Road, Salaya, Putthamonthon, 73170 Nakhon Pathom, Thailand
                Article
                DOI: 10.1039/D1BM00510C
                SO-VID: 240125fd-f651-48da-8234-b7c29febb0b7
                Copyright © © 2021
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                http://rsc.li/journals-terms-of-use

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