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      A New Indole Alkaloid from the Toad Venom of Bufo bufo gargarizans

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          Abstract

          A new indole alkaloid named bufobutarginine ( 1), along with three known bufotenines, namely, serotonin ( 2), bufotenidine ( 3), and bufotenine ( 4), were isolated from the water extract of toad venom. Their structures were elucidated by spectral methods. This is the first time that arginine has been found to be involved in the biosynthesis of bufotenines in parotid of toad. The cytotoxic activities of these compounds have been assayed against A375 and A549 cell lines by the MTT method; however, they showed no cytotoxic activities.

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          Bufothionine, a possible effective component in cinobufocini injection for hepatocellular carcinoma.

          Rui-Fang Xie, Zhi-Cheng Li, Bo Gao … (2012)
          Cinobufacini has been traditionally used in China for the treatment of tumor since hundreds years ago. For recent years, its modern preparation,cinobifucini injection has also obtained satisfactory therapeutic functions for cancer.
          Article 0 comments Cited 18 times – based on 0 reviews     Review now
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            Cytotoxic effects of mansonone E and F isolated from Ulmus pumila.

            Zheng Cui, Shin-ichi Tashiro, Dong Wang … (2004)
            Two sesquiterpenoids, mansonone E (ME) and mansonone F (MF) were first isolated from the dried root bark of Ulmus pumila (shironire in Japanese), and their antiproliferative activities on human tumor cells were evaluated in vitro. ME had more potent cytotoxic effects on four tumor cell lines, human cervical cancer HeLa, human malignant melanoma A375-S2, human breast cancer MCF-7, and human histiocytic lymphoma U937, than those of MF. The results showed that ME induced oligonucleosomal fragmentation of DNA in HeLa cells and activated caspase-3, followed by the degradation of the inhibitor of caspase-activated DNase, decreased the expression of anti-apoptotic mitochondrial proteins Bcl-2 and Bcl-(XL), and increased that of proapoptotic Bax.
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              New Amino Acid Derivatives from the Marine AscidianLeptoclinides dubius

              Ángel García, María Vázquez, Emilio Quiñoá … (1996)
              Article 0 comments Cited 6 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Thomas J. Schmidt: Role: Academic Editor
                Journal
                Journal ID (nlm-ta): Molecules
                Journal ID (iso-abbrev): Molecules
                Journal ID (publisher-id): molecules
                Title: Molecules
                Publisher: MDPI
                ISSN (Electronic): 1420-3049
                Publication date (Electronic): 16 March 2016
                Publication date Collection: March 2016
                Volume: 21
                Issue: 3
                Electronic Location Identifier: 349
                Affiliations
                [1 ]School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China; yhdai2008@ 123456aliyun.com (Y.-H.D.); sb.prove@ 123456163.com (B.S.); wangandong19891220@ 123456163.com (A.-D.W.); cyl855@ 123456163.com (Y.-L.C.); liudongchun@ 123456outlook.com (D.-C.L.)
                [2 ]School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China; xmywd@ 123456vip.sina.com
                [3 ]Laboratory of China-Korea Molecular Pharmacognosy, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China
                Author notes
                [* ]Correspondence: dongwang@ 123456syphu.edu.cn ; Tel.: +86-24-2398-4318
                [†]

                These authors contributed equally to this work.

                Article
                Publisher ID: molecules-21-00349
                DOI: 10.3390/molecules21030349
                PMC ID: 6273675
                PubMed ID: 26999086
                SO-VID: 243115e1-39ff-4bc1-b7e9-7a04f23a28b0
                Copyright © © 2016 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 23 January 2016
                Date accepted : 08 March 2016
                Categories
                Subject: Article

                Keywords: bufo bufo gargarizans,toad venom,bufobutarginine,cytotoxic activity
                Data availability:
                Keywords: bufo bufo gargarizans, toad venom, bufobutarginine, cytotoxic activity

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