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      Insight into oxidative stress in varicocele-associated male infertility: part 1.

      1 , ,

      Nature reviews. Urology

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          Abstract

          Varicocele is recognized as the leading cause of male infertility because it can impair spermatogenesis through several distinct pathophysiological mechanisms. Current evidence supports oxidative stress as a key element in the pathophysiology of varicocele-related infertility, although these mechanisms have not yet been fully described. Measurement of the reactive oxygen species and other markers of oxidative stress, including the levels of the antioxidant enzymes catalase and superoxide dismutase, can provide valuable information on the extent of oxidative stress and might guide therapeutic management strategies. The testis can respond to varicocele-associated cell stressors, such as heat stress, ischaemia or production of vasodilators (for example, nitric oxide) at the expense of the generation of excessive reactive oxygen species. These responses have their own implications in exacerbating the underlying oxidative stress and on the subsequent infertility.

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          Author and article information

          Journal
          Nat Rev Urol
          Nature reviews. Urology
          1759-4820
          1759-4812
          Dec 2012
          : 9
          : 12
          Affiliations
          [1 ] Center for Reproductive Medicine, Glickman Urological and Kidney Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. agarwaa@ccf.org
          Article
          nrurol.2012.197
          10.1038/nrurol.2012.197
          23165403
          24391fb4-9b60-4bf2-af7f-50c32f5d7f93

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