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      • Record: found
      • Abstract: found
      • Article: found

      Hydration and Elevated Calcium Alone Do Not Produce Xylose Nuclear Cataract: Role of Proteolysis by Calpain

      research-article
      Author(s): , ,
      Publication date (Electronic):
      Journal: Ophthalmic Research
      Publisher: S. Karger AG
      Keywords: E64, Calpain, Cataract, Xylose, Culture, Calcium

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          Abstract

          The purpose of this experiment was to determine the contribution of calpain proteolytic enzyme (EC 3.4.22.17) in the formation of nuclear cataract during lens culture in xylose. Increased lens calcium was found to be required for formation of xylose nuclear cataract in our culture system. Inhibition of calpain by the cysteine protease inhibitor E64 was effective in slowing the formation of nuclear cataract, even though lens calcium and hydration were markedly elevated. These results showed that hydration and elevated calcium alone do not produce xylose nuclear cataract, and they indicated that calpain proteolysis may be necessary for xylose nuclear cataract in the rat lens.

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          Author and article information

          Journal
          Journal ID (publisher-id): ORE
          Journal ID (nlm-ta): Ophthalmic Res
          Journal ID (doi): 10.1159/issn.0030-3747
          Title: Ophthalmic Research
          Publisher: S. Karger AG
          ISSN (Print): 0030-3747
          ISSN (Electronic): 1423-0259
          Publication date Subscription-year: 1992
          Publication date (Print): 1992
          Publication date (Electronic): 10 December 2009
          Volume: 24
          Issue: 1
          Pages: 8-14
          Affiliations
          Departments of Biochemistry and Ophthalmology, Schools of Medicine and Dentistry, Oregon Health Sciences University, Portland, Oreg., USA
          Article
          Publisher ID: 267138 Other ID: Ophthalmic Res 1992;24:8–14
          DOI: 10.1159/000267138
          PubMed ID: 1608594
          SO-VID: 245f8e13-307e-43dd-9b9f-4ec64c4cee7f
          Copyright © © 1992 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Date received : 22 February 1991
          Date accepted : 27 June 1991
          Page count
          Pages: 7
          Categories
          Subject: Original Paper

          ScienceOpen disciplines: Vision sciences,Ophthalmology & Optometry,Pathology
          Keywords: Culture,E64,Xylose,Calcium,Calpain,Cataract
          Data availability:
          ScienceOpen disciplines: Vision sciences, Ophthalmology & Optometry, Pathology
          Keywords: Culture, E64, Xylose, Calcium, Calpain, Cataract

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