Hadi Mirhedayati Roudsari , MD 1,a , Donghee Han , MD 1,a , Bríain ó Hartaigh , PhD 1 , Ji Hyun Lee , MD 1 , Asim Rizvi , MD 1 , Mahn-won Park , MD 1 , Bin Lu , MD 2 , Fay Y. Lin , MD 1 , James K. Min , MD , 1
Recent developments in the novel imaging technology of cardiac computed tomography (CT) not only permit detailed assessment of cardiac anatomy but also provide insight into cardiovascular physiology. Foremost, coronary CT angiography (CCTA) enables direct noninvasive examination of both coronary artery stenoses and atherosclerotic plaque characteristics. Calculation of computational fluid dynamics by cardiac CT allows the noninvasive estimation of fractional flow reserve, which increases the diagnostic accuracy for detection of hemodynamically significant coronary artery disease. In addition, a combination of myocardial CT perfusion and CCTA can provide simultaneous anatomical and functional assessment of coronary artery disease. Finally, detailed anatomical evaluation of atrial, ventricular, and valvular anatomy provides diagnostic information and guidance for procedural planning, such as for transcatheter aortic valve replacement. The clinical applications of cardiac CT will be extended with the development of these novel modalities.