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      Effect of Intrarenal Infusion of Angiotensin–(1–7) in the Dog

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          Abstract

          Angiotensin–(1–7), (Ang–(1–7)), a metabolite of Ang II and /or Ang I, was infused into the renal artery (i.r.a) of anesthetized dogs in order to demonstrate its possible direct renal action. The dose administered, 15 Ìg/kg BW/min in isotonic saline (0.072 ml/kg BW/min) throughout the experiment, did not influence the systemic arterial pressure and water and sodium excretion from the contralateral noninfused kidney. Renal blood flow (RBF) was measured by an electromagnetic flowmeter, glomerular filtration rate (GFR) by (exogenous) creatinine clearance. In other groups of animals, either EXP 3174, an AT–1 receptor antagonist alone (30 Ìg/kg BW/ min) or together with Ang–(1–7) (15 Ìg/kg BW/min), were infused. In the last group, the AT–2 receptor antagonist PD 123319, 10 Ìg/kg BW/min, was added to the infusion of Ang–(1–7). A small but significant decrease of RBF from 4.51±0.32 to 3.8±0.29 ml/g BW/min occurred after Ang–(1–7); this decrease was very similar when PD 123319 was added. However, an increase to 4.98±0.34 ml/g BW/min was seen after the addition of EXP 3174 to the i.r.a. infusion of Ang–(1–7); this increase was similar to the increase observed after EXP 3174 alone (5.21±0.33; p<0.02 in both cases). A very small but significant increase in GFR was seen after Ang–(1–7) + EXP 3174 or after the AT–1 blocker alone (0.64±0.049 and 0.62±0.05 vs. 0.6±0.05 ml/g BW/min in the Time Control Group, p<0.01 and 0.05, respectively). Water, sodium and urea excretion rates were increased in all groups infused with Ang–(1–7); after the combination of Ang–(1–7) + EXP 3174, all increases were higher than after every substance alone; however, statistical significance (p<0.05) was reached in sodium excretion values only. Potassium excretion rates were increased just in those groups in which EXP 3174 was present in the infusion fluid. In summary, Ang–(1–7) i.r.a. infusion in the dog is followed by increases in water, sodium and urea (but not potassium) excretion rates, highly probably of tubular origin. This effect is not completely blocked by the AT–1 – and not at all by the AT–2 receptor antagonist – thus indirectly suggesting another receptor could play a role. A small decrease in RBF disappears after EXP 3174, thus indicating an AT–1 receptor action.

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          Cardiovascular actions of angiotensin(1–7)

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            [7-D-ALA]-Angiotensin 1-7 Blocks Renal Actions of Angiotensin 1-7 in the Anesthetized Rat

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              Author and article information

              Journal
              KBR
              Kidney Blood Press Res
              10.1159/issn.1420-4096
              Kidney and Blood Pressure Research
              S. Karger AG
              1420-4096
              1423-0143
              2000
              2000
              24 March 2000
              : 23
              : 2
              : 89-94
              Affiliations
              aDepartment of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, and bRenal Section, Medical Policlinic, University of Bonn, Germany
              Article
              25959 Kidney Blood Press Res 2000;23:89–94
              10.1159/000025959
              10765110
              © 2000 S. Karger AG, Basel

              Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

              Page count
              Figures: 2, Tables: 2, References: 21, Pages: 6
              Product
              Self URI (application/pdf): https://www.karger.com/Article/Pdf/25959
              Categories
              Original Paper

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