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      A Novel Platelet-Derived Renal Vasoconstrictor Agent in Normotensives and Essential Hypertensives

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          Abstract

          Platelet homogenates from 200 ml blood of essential hypertensives (n = 28) and normotensives (n = 13) were deproteinized and separated by gel chromatography. The fractions obtained were then tested for vasopressor activity in the isolated perfused rat kidney. In both normotensives and hypertensives, two vasopressor fractions appeared. There was no difference in vasopressor activity in the first vasoactive fraction between normotensives and hypertensives. In the second vasoactive fraction, the hypertensive patients showed a significant higher activity than the normotensive subjects (increase in perfusion pressure by 35.9 ± 11.5 vs. 6.8 ± 5.3 mm Hg, p < 0.01). This vasopressor fraction was not inhibited by saralasin, phentolamine, ketanserin, nitroprusside and daltroban and was effective after pretreatment with indomethacin and reserpine and in enzymatically deendothelialized kidneys. The effect was reduced by nifedipine and unchanged by heating the fraction at 100°C and by incubation with proteinase K. It is concluded that a yet unidentified platelet-derived vasopressor agent may contribute to the enhanced vasoconstriction in essential hypertension.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1992
          1992
          23 September 2008
          : 29
          : 3
          : 281-289
          Affiliations
          Medizinische Poliklinik der Universität Münster, FRG
          Article
          158943 J Vasc Res 1992;29:281–289
          10.1159/000158943
          1324015
          © 1992 S. Karger AG, Basel

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          Page count
          Pages: 9
          Categories
          Research Paper

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