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      Obesity, inflammation, and atherosclerosis.

      1 ,
      Nature reviews. Cardiology
      Springer Science and Business Media LLC

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          Abstract

          Understanding of the pathophysiology of atherogenesis has evolved substantially during the last few decades. Atherosclerosis was once identified as a lipid-storage disease, but is now recognized as a subacute inflammatory condition of the vessel wall, characterized by infiltration of macrophages and T cells, which interact with one another and with cells of the arterial wall. The pathological mechanisms of obesity recapitulate many features of the inflammatory processes at work in atherosclerosis. Our current appreciation of the similarities between obesity and atherosclerosis has already fostered innovations for the diagnosis, prognosis, and prevention of these two conditions.

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          Author and article information

          Journal
          Nat Rev Cardiol
          Nature reviews. Cardiology
          Springer Science and Business Media LLC
          1759-5010
          1759-5002
          Jun 2009
          : 6
          : 6
          Affiliations
          [1 ] Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
          Article
          nrcardio.2009.55
          10.1038/nrcardio.2009.55
          19399028
          24da2ed2-3f31-488e-9766-1885d83bcb0e
          History

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