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      Membranous Glomerulonephritis Associated with Follicular B-Cell Lymphoma and Subepithelial Deposition of IgG1-κ Paraprotein

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          Abstract

          A case is described of B-cell lymphoma/chronic lymphocytic leukaemia associated with membranous glomerulonephritis in which the subepithelial deposits of immunoglobulin showed ĸ light chain restriction by immunofluorescence. Surface IgG-ĸ immunoglobulin was demonstrated on the malignant B cells, and a monoclonal protein of the same type was eluted from kidney. The mechanism of membranous glomerulonephritis in this type of lymphoid malignancy is clearly different from that in epithelial malignancies.

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          Author and article information

          Journal
          NEC
          Nephron Clin Pract
          10.1159/issn.1660-2110
          Nephron Clinical Practice
          S. Karger AG
          1660-2110
          2003
          March 2003
          17 November 2004
          : 93
          : 3
          : c112-c118
          Affiliations
          aRenal Section, Division of Medicine, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, bMolecular Immunopathology Unit, MRC Centre, Cambridge, and cDepartment of Neuroscience, Institute of Psychiatry, London, UK
          Article
          69548 Nephron Clin Pract 2003;93:c112–c118
          10.1159/000069548
          12660420
          © 2003 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Figures: 4, Tables: 1, References: 11, Pages: 1
          Product
          Self URI (application/pdf): https://www.karger.com/Article/Pdf/69548
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          Original Paper

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