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      Comparison of Simulated Workplace Protection Factors Offered by N95 and P100 Filtering Facepiece and Elastomeric Half-Mask Respirators against Particles of 10 to 400 nm

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          Abstract

          This study compared the simulated workplace protection factors (SWPFs) between NIOSH-approved N95 respirators and P100 respirators, including two models of filtering facepiece respirator (FFR) and two models of elastomeric half-mask respirator (EHR), against sodium chloride particles (NaCl) in a range of 10 to 400 nm.

          Twenty-five human test subjects performed modified OSHA fit test exercises in a controlled laboratory environment with the N95 respirators (two FFR models and two EHR models) and the P100 respirators (two FFRs and two EHRs). Two Scanning Mobility Particle Sizers (SMPS) were used to measure aerosol concentrations (in the 10–400 nm size range) inside (C in) and outside (C out) of the respirator, simultaneously. SWPF was calculated as the ratio of C out to C in. The SWPF values obtained from the N95 respirators were then compared to those of the P100 respirators.

          SWPFs were found to be significantly different (P<0.05) between N95 and P100 class respirators. The 10 th, 25 th, 50 th, 75 th and 90 th percentiles of the SWPFs for the N95 respirators were much lower than those for the P100 models. The N95 respirators had 5 th percentiles of the SWPFs > 10. In contrast, the P100 class was able to generate 5 th percentiles SWPFs > 100. No significant difference was found in the SWPFs when tested against nano-size (10 to 100 nm) and large-size (100 to 400 nm) particles.

          Overall, the findings suggest that the two FFRs and two EHRs with P100 class filters provide better performance than those with N95 filters against particles from 10 to 400 nm, supporting current OSHA and NIOSH recommendations.

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          Most cited references31

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          Manikin-based performance evaluation of N95 filtering-facepiece respirators challenged with nanoparticles.

          Protection of the human respiratory system from exposure to nanoparticles is becoming an emerging issue in occupational hygiene. The potential adverse health effects associated with particles of approximately 1-100 nm are probably greater than submicron or micron-sized particles. The performance of two models of N95 half-facepiece-filtering respirators against nano-sized particles was evaluated at two inhalation flow rates, 30 and 85 l min(-1), following a manikin-based protocol. The aerosol concentration was measured outside and inside the facepiece using the Wide-Range Particle Spectrometer. Sodium chloride particles, conventionally used to certify N-series respirators under NIOSH 42 CFR 84 regulations, were utilized as the challenge aerosol. The targeted particle sizes ranged from 10 to 600 nm, although the standard certification tests are performed with particles of approximately 300 nm, which is assumed to be the most penetrating size. The results indicate that the nanoparticle penetration through a face-sealed N95 respirator may be in excess of the 5% threshold, particularly at high respiratory flow rates. Thus, N95 respirators may not always provide the expected respiratory protection for workers. The highest penetration values representing the poorest respirator protection conditions were observed in the particle diameter range of approximately 30-70 nm. Based on the theoretical simulation, we have concluded that for respirators utilizing mechanical filters, the peak penetration indeed occurs at the particle diameter of approximately 300 nm; however, for pre-charged fiber filters, which are commonly used for N95 respirators, the peak shifts toward nano-sizes. This study has confirmed that the neutralization of particles is a crucial element in evaluating the efficiency of a respirator. The variability of the respirator's performance was determined for both models and both flow rates. The analysis revealed that the coefficient of variation of the penetration ranged from 0.10 to 0.54 for particles of 20-100 nm in diameter. The fraction of N95 respirators for which the performance test at 85 l min(-1) demonstrated excessive (>5%) penetration of nanoparticles was as high as 9/10. The test results obtained in a relatively small (0.096 m(3)) test chamber and in a large (24.3 m(3)) walk-in chamber were found essentially the same, thus, suggesting that laboratory-based evaluations have a good potential to adequately represent the respirator field performance.
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            Fitting characteristics of eighteen N95 filtering-facepiece respirators.

            Four performance measures were used to evaluate the fitting characteristics of 18 models of N95 filtering-facepiece respirators: (1) the 5th percentile simulated workplace protection factor (SWPF) value, (2) the shift average SWPF value, (3) the h-value, and (4) the assignment error. The effect of fit-testing on the level of protection provided by the respirators was also evaluated. The respirators were tested on a panel of 25 subjects with various face sizes. Simulated workplace protection factor values, determined from six total penetration (face-seal leakage plus filter penetration) tests with re-donning between each test, were used to indicate respirator performance. Five fit-tests were used: Bitrex, saccharin, generated aerosol corrected for filter penetration, PortaCount Plus corrected for filter penetration, and the PortaCount Plus with the N95-Companion accessory. Without fit-testing, the 5th percentile SWPF for all models combined was 2.9 with individual model values ranging from 1.3 to 48.0. Passing a fit-test generally resulted in an increase in protection. In addition, the h-value of each respirator was computed. The h-value has been determined to be the population fraction of individuals who will obtain an adequate level of protection (i.e., SWPF >/=10, which is the expected level of protection for half-facepiece respirators) when a respirator is selected and donned (including a user seal check) in accordance with the manufacturer's instructions without fit-testing. The h-value for all models combined was 0.74 (i.e., 74% of all donnings resulted in an adequate level of protection), with individual model h-values ranging from 0.31 to 0.99. Only three models had h-values above 0.95. Higher SWPF values were achieved by excluding SWPF values determined for test subject/respirator combinations that failed a fit-test. The improvement was greatest for respirator models with lower h-values. Using the concepts of shift average and assignment error to measure respirator performance yielded similar results. The highest level of protection was provided by passing a fit-test with a respirator having good fitting characteristics.
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              Occupational risk management of engineered nanoparticles.

              The earliest and most extensive societal exposures to engineered nanoparticles are likely to occur in the workplace. Until toxicologic and health effects research moves forward to characterize more broadly the potential hazards of nanoparticles and to provide a scientific basis for appropriate control of nanomaterials in the workplace, current and future workers may be at risk from occupational exposures. This article reviews a conceptual framework for occupational risk management as applied to engineered nanomaterials and describes an associated approach for controlling exposures in the presence of uncertainty. The framework takes into account the potential routes of exposure and factors that may influence biological activity and potential toxicity of nanomaterials; incorporates primary approaches based on the traditional industrial hygiene hierarchy of controls involving elimination or substitution, engineering controls, administrative controls, and use of personal protective equipment; and includes valuable secondary approaches involving health surveillance and medical monitoring.
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                Author and article information

                Journal
                101664422
                44162
                J Nanotechnol Mater Sci
                J Nanotechnol Mater Sci
                Journal of nanotechnology and materials science
                2377-1372
                31 July 2015
                7 September 2015
                07 September 2015
                : 2
                : 2
                : 1-6
                Affiliations
                [1 ]National Institute for Occupational Safety and Health, National Personal Protective Technology Laboratory, Pittsburgh, PA
                [2 ]URS, Inc. Pittsburgh, PA
                [3 ]Industrial and Management Systems Engineering, College of Engineering and Mineral Resources, West Virginia University, Morgantown, WV
                [4 ]Institute of Health Surveillance, Analysis and Protection, Hubei Center for Disease Control and Prevention, Wuhan, Hubei, China
                Author notes
                [* ] Corresponding author: Ziqing Zhuang, NIOSH-NPPTL, 626 Cochrans Mill Road, Pittsburgh, PA 15236, USA; Tel: +1 4123864055. zaz3@ 123456cdc.gov
                Article
                HHSPA709765
                10.15436/2377-1372.15.015
                4529391
                26273701
                24e1070f-8273-47ba-8fa2-0c8684bdf3fd

                This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.

                Categories
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                nano particle,n95,p100,ffr,her,swpf,respirator
                nano particle, n95, p100, ffr, her, swpf, respirator

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