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      Soft lithography in biology and biochemistry.

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          Abstract

          Soft lithography, a set of techniques for microfabrication, is based on printing and molding using elastomeric stamps with the patterns of interest in basrelief. As a technique for fabricating microstructures for biological applications, soft lithography overcomes many of the shortcomings of photolithography. In particular, soft lithography offers the ability to control the molecular structure of surfaces and to pattern the complex molecules relevant to biology, to fabricate channel structures appropriate for microfluidics, and to pattern and manipulate cells. For the relatively large feature sizes used in biology (> or = 50 microns), production of prototype patterns and structures is convenient, inexpensive, and rapid. Self-assembled monolayers of alkanethiolates on gold are particularly easy to pattern by soft lithography, and they provide exquisite control over surface biochemistry.

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          Author and article information

          Journal
          Annu Rev Biomed Eng
          Annual review of biomedical engineering
          Annual Reviews
          1523-9829
          1523-9829
          2001
          : 3
          Affiliations
          [1 ] Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA. gwhitesides@gmwgroup.harvard.edu
          Article
          3/1/335
          10.1146/annurev.bioeng.3.1.335
          11447067
          2503560b-473c-4957-aa1b-2d7295072319
          History

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