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      Auxiliary subunits: essential components of the voltage-gated calcium channel complex

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      Current Opinion in Neurobiology
      Elsevier BV

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          Abstract

          Voltage-gated calcium channels are important mediators of several physiological processes, including neuronal excitability and muscle contraction. At the molecular level, the channels are composed of four subunits--the pore forming alpha(1) subunit and the auxiliary alpha(2)delta, beta and gamma subunits. The auxiliary subunits modulate the trafficking and the biophysical properties of the alpha(1) subunit. In the past several years there has been an acceleration of our understanding of the auxiliary subunits, primarily because of their molecular characterization and the availability of spontaneous and targeted mouse mutants. These studies have revealed the crucial role of the subunits in the functional effects that are mediated by voltage-gated calcium channels.

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          Author and article information

          Journal
          Current Opinion in Neurobiology
          Current Opinion in Neurobiology
          Elsevier BV
          09594388
          June 2003
          June 2003
          : 13
          : 3
          : 298-307
          Article
          10.1016/S0959-4388(03)00066-7
          12850214
          2505b752-0e42-4c0a-a173-44a55a9d3732
          © 2003

          https://www.elsevier.com/tdm/userlicense/1.0/

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