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      Modulation of Hippocampal Glucocorticoid and Mineralocorticoid Receptor mRNA Expression by Amygdaloid Kindling

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          Abstract

          In situ hybridization was used to examine the effects of amygdala kindling on the expression of mRNAs for mineralocorticoid receptors (MR) and glucocorticoid receptors (GR) in the rat hippocampus. Kindling increased MR mRNA levels in the dentate gyms of the hippocampus 4 h after the last seizure, and these levels remained elevated 24 h later, but returned to baseline at 4 days. The only other hippocampal region that showed changes was the ipsilateral CA2 subfield where MR mRNA was significantly increased only at the 4-hour time point. Kindling also increased the levels of GR mRNA in the dentate gyms at 4 h; however, GR mRNA levels significantly decreased below control values at 24 h before returning to normal at 4 days. These data indicate differential transient alterations in hippocampal MR and GR receptor mRNA expression following amygdala-kindled seizures.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1994
          1994
          08 April 2008
          : 59
          : 5
          : 451-456
          Affiliations
          Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Md., USA
          Article
          126691 Neuroendocrinology 1994;59:451–456
          10.1159/000126691
          8022520
          © 1994 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Neuronal Regulation

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