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The beta3 subunit of the Na+,K+-ATPase mediates variable nociceptive sensitivity in the formalin test.

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      Abstract

      It is widely appreciated that there is significant inter-individual variability in pain sensitivity, yet only a handful of contributing genetic variants have been identified. Computational genetic mapping and quantitative trait locus analysis suggested that variation within the gene coding for the beta3 subunit of the Na+,K+-ATPase pump (Atp1b3) contributes to inter-strain differences in the early phase formalin pain behavior. Significant strain differences in Atp1b3 gene expression, beta3 protein expression, and biophysical properties of the Na+,K+ pump in dorsal root ganglia neurons from resistant (A/J) and sensitive (C57BL/6J) mouse strains supported the genetic prediction. Furthermore, in vivo siRNA knockdown of the beta3 subunit produced strain-specific changes in the early phase pain response, completely rescuing the strain difference. These findings indicate that the beta3 subunit of the Na+,K+-ATPase is a novel determinant of nociceptive sensitivity and further supports the notion that pain variability genes can have very selective effects on individual pain modalities.

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      Affiliations
      [1 ] Department of Psychology and Centre for Research on Pain, McGill University, 1205 Dr. Penfield Ave., Montreal, Que. H3A 1B1, Canada.
      Journal
      Pain
      Pain
      Elsevier BV
      1872-6623
      0304-3959
      Aug 2009
      : 144
      : 3
      19464798 S0304-3959(09)00253-X 10.1016/j.pain.2009.04.028 2744953 NIHMS128994

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