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      Prefrontal–hippocampal interactions in episodic memory

      Nature Reviews Neuroscience

      Springer Nature

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          Abstract

          The prefrontal cortex and the hippocampus have distinct and complementary roles in episodic memory, and their interactions are also crucial for memory. Eichenbaum describes the pathways and mechanisms mediating these interactions and suggests a model of how these regions communicate to retrieve cued memories.

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          Most cited references 120

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          Loss of recent memory after bilateral hippocampal lesions.

           B Milner,  W SCOVILLE (1957)
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            The role of medial prefrontal cortex in memory and decision making.

            Some have claimed that the medial prefrontal cortex (mPFC) mediates decision making. Others suggest mPFC is selectively involved in the retrieval of remote long-term memory. Yet others suggests mPFC supports memory and consolidation on time scales ranging from seconds to days. How can all these roles be reconciled? We propose that the function of the mPFC is to learn associations between context, locations, events, and corresponding adaptive responses, particularly emotional responses. Thus, the ubiquitous involvement of mPFC in both memory and decision making may be due to the fact that almost all such tasks entail the ability to recall the best action or emotional response to specific events in a particular place and time. An interaction between multiple memory systems may explain the changing importance of mPFC to different types of memories over time. In particular, mPFC likely relies on the hippocampus to support rapid learning and memory consolidation. Copyright © 2012 Elsevier Inc. All rights reserved.
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              Interplay of hippocampus and prefrontal cortex in memory.

              Recent studies on the hippocampus and the prefrontal cortex have considerably advanced our understanding of the distinct roles of these brain areas in the encoding and retrieval of memories, and of how they interact in the prolonged process by which new memories are consolidated into our permanent storehouse of knowledge. These studies have led to a new model of how the hippocampus forms and replays memories and how the prefrontal cortex engages representations of the meaningful contexts in which related memories occur, as well as how these areas interact during memory retrieval. Furthermore, they have provided new insights into how interactions between the hippocampus and prefrontal cortex support the assimilation of new memories into pre-existing networks of knowledge, called schemas, and how schemas are modified in this process as the foundation of memory consolidation. Copyright © 2013 Elsevier Ltd. All rights reserved.
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                Author and article information

                Journal
                Nature Reviews Neuroscience
                Nat Rev Neurosci
                Springer Nature
                1471-003X
                1471-0048
                June 29 2017
                June 29 2017
                :
                :
                Article
                10.1038/nrn.2017.74
                25172456-8430-4890-bcce-0f9e84a6331d
                © 2017
                Product

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