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      Native mass spectrometry: a bridge between interactomics and structural biology.

      Nature Methods

      metabolism, chemistry, Proteins, Protein Binding, methods, Molecular Biology, Mass Spectrometry, Humans, Biochemistry, Animals

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          Abstract

          Native mass spectrometry is an emerging technology that allows the topological investigation of intact protein complexes with high sensitivity and a theoretically unrestricted mass range. This unique tool provides complementary information to established technologies in structural biology, and also provides a link to high-throughput interactomics studies, which do not generate information on exact protein complex-composition, structure or dynamics. Here I review the current state of native mass spectrometry technology and discuss several important biological applications. I also describe current experimental challenges in native mass spectrometry, encouraging readers to contribute to solutions.

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          Journal
          18974734
          10.1038/nmeth.1265

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