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      Tumor Necrosis Factor/Cachectin-Induced Modulation of Endothelial Cell Hemostatic Properties

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      Oncology Research and Treatment

      S. Karger AG

      Endothelium-coagulation, Tumor necrosis factor

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          Abstract

          Tumor necrosis factor/cachectin (TNF) is a mediator of the septic shock state, which can modulate hemostatic properties of the vessel wall. The interaction of TNF with endothelium is not cytotoxic, rather it is receptor mediated and results in a change in receptor expression on the endothelial cell surface, enabling endothelium to actively promote coagulation. Anticoagulant mechanisms, including the protein C/protein S system and fibrinolysis are suppressed, whereas the initiation and propagation of procoagulant activity is enhanced. This unidirectional shift in vessel wall coagulant activity favoring clot formation could contribute to the coagulopathy associated with sepsis and indicates a mechanism through which the coagulation system serves as an integral part of the host response.

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          Author and article information

          Journal
          ONK
          Oncol Res Treat
          10.1159/issn.2296-5270
          Oncology Research and Treatment
          S. Karger AG
          978-3-8055-4720-8
          978-3-318-05762-1
          2296-5270
          2296-5262
          1987
          1987
          24 April 2009
          : 10
          : 4
          : 254-258
          Affiliations
          Oklahoma Medical Research Foundation, Oklahoma City, Okla., USA
          Article
          216415 Onkologie 1987;10:254–258
          10.1159/000216415
          2823200
          © 1987 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Product
          Self URI (application/pdf): https://www.karger.com/Article/Pdf/216415
          Categories
          Endothel und Thrombozyten

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