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      Amantadine Toxicity in a Patient with Renal Insufficiency

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          Abstract

          In a patient with chronic renal failure and maintained with regular hemodialysis, the development of neuropsychiatric untoward effects during amantadine therapy was associated with an inordinately elevated plasma level of the drug. It is recommended that in the face of renal inadequacy, adjustment of the dosage of the drug should be done in accordance with the degree of renal dysfunction.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1974
          1974
          28 November 2008
          : 13
          : 2
          : 183-186
          Affiliations
          Departments of Medicine, Psychiatry and Neurology, Rush-Presbyterian-St. Luke’s Medical Center, and Rush Medical College, Chicago, Ill.
          Article
          180391 Nephron 1974;13:183–186
          10.1159/000180391
          4850491
          2556c628-dddf-4ae2-a61d-1bc8c33fa1f6
          © 1974 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 02 November 1973
          : 22 December 1973
          Page count
          Pages: 4
          Categories
          Case Report

          Cardiovascular Medicine,Nephrology
          Amantadine toxicity,Renal insufficiency
          Cardiovascular Medicine, Nephrology
          Amantadine toxicity, Renal insufficiency

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