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      Serum proteomic profiling can discriminate prostate cancer from benign prostates in men with total prostate specific antigen levels between 2.5 and 15.0 ng/ml.

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          Abstract

          Artificial intelligence based pattern recognition algorithms have been developed and successfully used to analyze complex serum proteomic data streams generated by surface enhanced, laser desorption ionization time-of-flight mass spectroscopy. In the current study we used a high performance, hybrid quadrupole time-of-flight mass spectrometer to generate discriminatory serum proteomic profiles to determine if this technology could be used to determine the need for prostate biopsy in men with elevated prostate specific antigen (PSA).

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          Author and article information

          Journal
          J. Urol.
          The Journal of urology
          0022-5347
          0022-5347
          Oct 2004
          : 172
          : 4 Pt 1
          Affiliations
          [1 ] Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA. dornestei@uci.edu
          Article
          00005392-200410000-00019
          10.1097/01.ju.0000139572.88463.39
          15371828
          2586a0e4-1b87-4055-a887-897c1da89f4f
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