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      Antiviral activity of lignans and their glycosides from Justicia procumbens

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      Phytochemistry
      Elsevier BV

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          Abstract

          Ten antiviral lignans, seven known (justicidins A, B, C and D, diphyllin, diphyllin apioside and diphyllin apioside-5-acetate) and three new compounds, justicidinosides A (justicidin C 6'-O-glucoside), B (justicidin A 6'-O-glucoside) and C (justicidin B 6'-O-glucoside), were isolated from a methanolic extract of the aerial parts of Justicia procumbens var. leucantha. Justicidins A and B, diphyllin, diphyllin apioside and diphyllin apioside-5-acetate showed strong antiviral activity (the MIC were less than 0.25 microgram ml-1, respectively) against vesicular stomatitis virus and low cytotoxicity (the MTC were larger than 31 micrograms ml-1, respectively) against cultured rabbit lung cells (RL-33).

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          Author and article information

          Journal
          Phytochemistry
          Phytochemistry
          Elsevier BV
          00319422
          June 1996
          June 1996
          : 42
          : 3
          : 713-717
          Article
          10.1016/0031-9422(96)00024-6
          8768323
          25d2caeb-f8dc-4528-8751-fc78413c5a03
          © 1996

          https://www.elsevier.com/tdm/userlicense/1.0/

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