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      Cardamonin exerts anti-gastric cancer activity via inhibiting LncRNA-PVT1-STAT3 axis

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          Abstract

          Background: Gastric cancer is one of the most commonly diagnosed cancers each year, and it remains the third leading cause of cancer death in the world. The clinicopathologic characteristics differ among regions, so epigenetic changes play a key role in gastric carcinogenesis. Methods: In the present study, we first demonstrate that cardamonin, a natural production of chalcone, is an anti-gastric cancer agent in pre-clinical evaluation. Results: Cardamonin inhibited proliferation and migration, induced apoptosis in gastric cancer cells. It could reduce the expression of apoptosis-related and migration-related genes and proteins. The constant activation of STAT3 (signal transducer and activator of transcription 3) signal is a major intrinsic signal for cancer inflammation. It regulates cellular proliferation, cell cycle, and migration that are critical for cancer procession. Cardamonin could effectively down-regulate p-STAT3 and abolish activation of STAT3 through inhibiting the expression of LncRNA-PVT1. Conclusion: The present study revealed that cardamonin is a potential natural source of anti-gastric cancer drugs via epigenetic mechanism to inhibit LncRNA-PVT1-STAT3 axis.

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          Epidemiology of gastric cancer

          Katherine D Crew, Alfred I Neugut (2006)
          Article 0 comments Cited 201 times – based on 0 reviews     Review now
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            Gastric Adenocarcinoma : Review and Considerations for Future Directions

            Bryan Dicken, David L. Bigam, Carol Cass … (2005)
            This update reviews the epidemiology and surgical management, and the controversies of gastric adenocarcinoma. We provide the relevance of outcome data to surgical decision-making and discuss the application of gene-expression analysis to clinical practice. Gastric cancer mortality rates have remained relatively unchanged over the past 30 years, and gastric cancer continues to be one of the leading causes of cancer-related death. Well-conducted studies have stimulated changes to surgical decision-making and technique. Microarray studies linked to predictive outcome models are poised to advance our understanding of the biologic behavior of gastric cancer and improve surgical management and outcome. We performed a review of the English gastric adenocarcinoma medical literature (1980-2003). This review included epidemiology, pathology and staging, surgical management, issues and controversies in management, prognostic variables, and the application of outcome models to gastric cancer. The results of DNA microarray analysis in various cancers and its predictive abilities in gastric cancer are considered. Prognostic studies have provided valuable data to better the understanding of gastric cancer. These studies have contributed to improved surgical technique, more accurate pathologic characterization, and the identification of clinically useful prognostic markers. The application of microarray analysis linked to predictive models will provide a molecular understanding of the biology driving gastric cancer. Predictive models generate important information allowing a logical evolution in the surgical and pathologic understanding and therapy for gastric cancer. However, a greater understanding of the molecular changes associated with gastric cancer is needed to guide surgical and medical therapy.
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              Amplification of PVT-1 is involved in poor prognosis via apoptosis inhibition in colorectal cancers

              Y. Takahashi, S G Sawada, J Kurashige … (2013)
              Background: We previously conducted gene expression microarray analyses to identify novel indicators for colorectal cancer (CRC) metastasis and prognosis from which we identified PVT-1 as a candidate gene. PVT-1, which encodes a long noncoding RNA, mapped to chromosome 8q24 whose copy-number amplification is one of the most frequent events in a wide variety of malignant diseases. However, PVT-1 molecular mechanism of action remains unclear. Methods: We conducted cell proliferation and invasion assays using colorectal cancer cell lines transfected with PVT-1siRNA or negative control siRNA. Gene expression microarray analyses on these cell lines were also carried out to investigate the molecular function of PVT-1. Further, we investigated the impact of PVT-1 expression on the prognosis of 164 colorectal cancer patients by qRT–PCR. Results: CRC cells transfected with PVT-1 siRNA exhibited significant loss of their proliferation and invasion capabilities. In these cells, the TGF-β signalling pathway and apoptotic signals were significantly activated. In addition, univariate and multivariate analysis revealed that PVT-1 expression level was an independent risk factor for overall survival of colorectal cancer patients. Conclusion: PVT-1, which maps to 8q24, generates antiapoptotic activity in CRC, and abnormal expression of PVT-1 was a prognostic indicator for CRC patients.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Biosci Rep
                Journal ID (iso-abbrev): Biosci. Rep
                Journal ID (hwp): ppbioscirep
                Journal ID (publisher-id): BSR
                Title: Bioscience Reports
                Publisher: Portland Press Ltd.
                ISSN (Print): 0144-8463
                ISSN (Electronic): 1573-4935
                Publication date (Electronic preprint): 26 April 2019
                Publication date Collection: 31 May 2019
                Publication date (Electronic): 17 May 2019
                Volume: 39
                Issue: 5
                Electronic Location Identifier: BSR20190357
                Affiliations
                [1 ]Department of General Surgery, Northern Jiangsu Province Hospital, Clinical Medical College, Institute of General Surgery – Yangzhou, Yangzhou University, Yangzhou, P.R. China
                [2 ]Department of General Surgery, The Second Xiang ya Hospital of Central South University, Changsha, P.R. China
                Author notes
                Correspondence: Daorong Wang ( wdaorong666@ 123456sina.com ) or Dong Tang ( 83392785@ 123456qq.com )
                Author information
                http://orcid.org/0000-0003-1642-0889
                Article
                DOI: 10.1042/BSR20190357
                PMC ID: 6522749
                PubMed ID: 31028131
                SO-VID: 25d96cca-da7d-4f18-baf2-1fe295288ef2
                Copyright © © 2019 The Author(s).
                License:

                This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).

                History
                Date received : 12 February 2019
                Date revision received : 23 April 2019
                Date accepted : 24 April 2019
                Page count
                Pages: 9
                Categories
                Subject: Research Articles
                Subject: Research Article
                Subject: 39
                Subject: 49
                Subject: 13

                ScienceOpen disciplines: Life sciences
                Keywords: cardamonin,gastric cancer,inflammation,lncrna-pvt1
                Data availability:
                ScienceOpen disciplines: Life sciences
                Keywords: cardamonin, gastric cancer, inflammation, lncrna-pvt1

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