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      Antibacterial resistance worldwide: causes, challenges and responses.

      1 ,
      Nature medicine
      Springer Science and Business Media LLC

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          Abstract

          The optimism of the early period of antimicrobial discovery has been tempered by the emergence of bacterial strains with resistance to these therapeutics. Today, clinically important bacteria are characterized not only by single drug resistance but also by multiple antibiotic resistance--the legacy of past decades of antimicrobial use and misuse. Drug resistance presents an ever-increasing global public health threat that involves all major microbial pathogens and antimicrobial drugs.

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          Author and article information

          Journal
          Nat Med
          Nature medicine
          Springer Science and Business Media LLC
          1078-8956
          1078-8956
          Dec 2004
          : 10
          : 12 Suppl
          Affiliations
          [1 ] Center for Adaptation Genetics and Drug Resistance, Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.
          Article
          nm1145
          10.1038/nm1145
          15577930
          25dcbe11-d18b-416b-92b0-c2eea84d69bc
          History

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