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IL-25 Induces IL-4, IL-5, and IL-13 and Th2-Associated Pathologies In Vivo
Madeline M. Fort ,
Jeanne Cheung ,
David Yen ,
Joana Li ,
Sandra M. Zurawski ,
Sylvia Lo ,
Satish Menon ,
Teresa Clifford ,
Brisdell Hunte ,
Robin Lesley ,
Tony Muchamuel ,
Stephen D. Hurst ,
Gerard Zurawski ,
Michael W. Leach ,
Daniel M. Gorman ,
Donna M. Rennick
December 2001
December 2001
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Abstract
We have characterized a cytokine produced by Th2 cells, designated as IL-25. Infusion
of mice with IL-25 induced IL-4, IL-5, and IL-13 gene expression. The induction of
these cytokines resulted in Th2-like responses marked by increased serum IgE, IgG(1),
and IgA levels, blood eosinophilia, and pathological changes in the lungs and digestive
tract that included eosinophilic infiltrates, increased mucus production, and epithelial
cell hyperplasia/hypertrophy. In addition, our studies show that IL-25 induces Th2-type
cytokine production by accessory cells that are MHC class II(high), CD11c(dull), and
lineage(-). These results suggest that IL-25, derived from Th2 T cells, is capable
of amplifying allergic type inflammatory responses by its actions on other cell types.