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      Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin.

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          Abstract

          Lactobacilli are probiotic bacteria that are frequently tested in the management of allergic diseases or gastroenteritis. It is hypothesized that these probiotics have immunoregulatory properties and promote mucosal tolerance, which is in part mediated by regulatory T cells (Treg cells). On the basis of pathogenic or tissue-specific priming, dendritic cells (DC) acquire different T cell-instructive signals and drive the differentiation of naive T H cells into either T H 1, T H 2, or regulatory effector T cells.

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          Author and article information

          Journal
          J Allergy Clin Immunol
          The Journal of allergy and clinical immunology
          Elsevier BV
          0091-6749
          0091-6749
          Jun 2005
          : 115
          : 6
          Affiliations
          [1 ] Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands.
          Article
          S0091674905006974
          10.1016/j.jaci.2005.03.036
          15940144
          25ec8729-c8f1-440c-823b-d0322b12cf5b
          History

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