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      Derailed endocytosis: an emerging feature of cancer.

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          Abstract

          Once engaged by soluble or matrix-anchored ligands, cell surface proteins are commonly sorted to lysosomal degradation through several endocytic pathways. Defective vesicular trafficking of growth factor receptors, as well as unbalanced recycling of integrin- and cadherin-based adhesion complexes, has emerged in the past 5 years as a multifaceted hallmark of malignant cells. In line with the cooperative nature of endocytic machineries, multiple oncogenic alterations underlie defective endocytosis, such as altered ubiquitylation (Cbl and Nedd4 ubiquitin ligases, for example), altered cytoskeletal interactions and alterations to Rab family members. Pharmaceutical interception of the propensity of tumour cells to derail their signalling and their adhesion receptors may constitute a novel target for cancer therapy.

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          Author and article information

          Journal
          Nat Rev Cancer
          Nature reviews. Cancer
          Springer Science and Business Media LLC
          1474-1768
          1474-175X
          Nov 2008
          : 8
          : 11
          Affiliations
          [1 ] Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel.
          Article
          nrc2521
          10.1038/nrc2521
          18948996
          25edb111-047f-45bf-b689-c0a3f2f64b38

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