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      Presence of Contractile-Type Smooth Muscle Cells in the Endocardium

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          Abstract

          A smooth muscle layer exists in the parietal endocardium. Notwithstanding previous pioneer work, little has been known on the phenotypes of these smooth muscles. In humans as in animals, smooth muscles show two distinct phenotypes, the ‘synthetic’ and ‘contractile’ states, which can be differentiated on the basis of the expression of two types of myosin heavy chain isoforms, SMI and SM2. In this study, using SMI- and SM2-specific monoclonal antibodies, we performed immunohistochemical examinations to determine the phenotype of the endocardial smooth muscles. We report here that the endocardial smooth muscles have the contractile phenotype.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1996
          1996
          19 November 2008
          : 87
          : 1
          : 23-27
          Affiliations
          aThird and bSecond Departments of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
          Article
          177055 Cardiology 1996;87:23–27
          10.1159/000177055
          8631040
          © 1996 S. Karger AG, Basel

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          Page count
          Pages: 5
          Categories
          General Cardiology, Basic Science

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