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      Cytokine production and treatment response in major depressive disorder.

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          Abstract

          In a controlled study, such immunological parameters as whole blood production of the cytokines interleukin-6 (IL-6) and tumor-necrosis factor-alpha (TNF-alpha) were assessed in 24 inpatients with a major depressive disorder (MDD) both before and again under treatment. After a 6-week treatment period with amitriptyline, patients were classified as responders or nonresponders according to their psychopathological outcome as evaluated by the Hamilton and the Montgomery-Asberg Depression Rating Scales. Pre-treatment levels of c-reactive protein (CRP) were significantly higher in both patient subgroups than in the control subjects. In comparison to the controls, unstimulated pretreatment production of IL-6 was significantly decreased in the responders; whereas it was significantly increased in the nonresponder subgroup. Post-treatment values did not differ significantly among the patient and control groups. Pretreatment levels of TNF-alpha were increased in both patient subgroups, with a significant decrease during treatment only in the responder subgroup. Pretreatment levels of IL-6/10(5) mononuclear cells and the ratio between lymphocytes and monocytes acted as independent variables with regard to the clinical response. Our data indicate that unstimulated secretion of TNF-alpha is related to the psychopathological improvement; whereas, IL-6 levels might dichotomize the patients into subsequent responders and nonresponders already at admission.

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          Author and article information

          Journal
          Neuropsychopharmacology
          Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
          Elsevier BV
          0893-133X
          0893-133X
          Apr 2000
          : 22
          : 4
          Affiliations
          [1 ] Department of Psychiatry and Psychotherapy, Philipps-University of Marburg, Marburg, Germany.
          Article
          S0893-133X(99)00134-7
          10.1016/S0893-133X(99)00134-7
          10700656
          262233ee-ccdd-4472-bb01-48d49730d0c7
          History

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