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      Diagnosing acute HIV infection at point of care: a retrospective analysis of the sensitivity and specificity of a fourth-generation point-of-care test for detection of HIV core protein p24.

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          Abstract

          Detection of acute HIV infection is vital in preventing onward transmission. HIV point-of-care testing (POCT) has improved uptake of HIV testing but has been limited to third-generation assays, which only detect chronic HIV infection. Previous evaluation of the fourth-generation Alere Determine HIV-1/2 Ag/Ab Combo POCT showed only 50% sensitivity for HIV core protein p24 (p24 antigen) detection, which is suboptimal for diagnosis of acute HIV infection with limited advantage over third-generation POCT. We aimed to assess the sensitivity of the new Alere HIV Combo POCT to detect acute HIV infection.

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          Author and article information

          Journal
          Sex Transm Infect
          Sexually transmitted infections
          BMJ
          1472-3263
          1368-4973
          Mar 2017
          : 93
          : 2
          Affiliations
          [1 ] Department of Genito-Urinary Medicine, Guy's and St Thomas' NHS Foundation Trust, London, UK.
          [2 ] Infection Sciences, Virology Section, Viapath, Guy's and St Thomas' NHS Foundation Trust, London, UK.
          Article
          sextrans-2015-052491
          10.1136/sextrans-2015-052491
          27272704
          262d9801-7851-412d-9d1f-a010adb9602a

          ANTIGEN DETECTION,DIAGNOSIS,HIV,HIV TESTING,PRIMARY HIV INFECTION

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