Evaluation of local trace element status and 8-Iso-prostaglandin F2α concentrations in patients with Tinea pedis

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Abstract

Background

Tinea pedis (TP) is an infection of the feet caused by fungi. The infectious diseases caused by dermatophytes are mainly related to the enzymes produced by these fungi. Up to the now, the local 8-iso-prostaglandin F _2α (8-iso-PGF _2α), concentration as oxidative stress biomarker and trace elements status have not been published in patients with TP. The aim of this study is to evaluate the relationship between oxidative stress and trace elements (Cu, Zn, Se), and to evaluate the ratios of Cu/Zn and Cu/Se in this disorder.

Methods

Forty-three consecutive patients with a diagnosis of unilateral interdigital TP were enrolled in this study. The samples were obtained by scraping the skin surface. 8-iso-PGF _2α concentrations in scraping samples were determined by ELISA. In addition, the levels of Se, Zn and Cu in scraping samples were determined on flame and furnace atomic absorption spectrophotometer using Zeeman background correction.

Results

Oxidative stress was confirmed by the significant elevation in 8-iso-PGF _2α concentrations ( p < 0.05). When compared to non-lesional area, Zn and Se levels were significantly lower on lesional area, whereas Cu levels was higher on the lesional area than the non-lesional area ( p < 0.05). In addition, the correlation results of this study were firstly shown that there were significant and positive correlations between Cu and 8-iso-PGF _2α parameters, but negative correlations between Se-Cu; Se-8-iso-PGF _2α parameters in lesional area. Furthermore, the ratios of Cu/Zn and Cu/Se were significantly higher on the lesional area than the non-lesional area ( p < 0.05). According to sex and fungal subtypes, there was no significant difference in the concentrations of 8-iso-PGF _2α and trace elements in patients with TP ( p > 0.05).

Conclusions

Our results showed that there is a possible link between oxidative stress (increased 8-iso-PGF _2α concentrations) and imbalanced of trace elements status in lesional area of TP patients. The use of antifungal agents together with both Zn and Se drugs could be helpful in the both regression of disease and in shortening the duration of disease.

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A large body of evidence suggests that a significant percentage of deaths resulting from cancer in the United States could be avoided through greater attention to proper and adequate nutrition. Although many dietary compounds have been suggested to contribute to the prevention of cancer, there is strong evidence to support the fact that zinc, a key constituent or cofactor of over 300 mammalian proteins, may be of particular importance in host defense against the initiation and progression of cancer. Remarkably, 10% of the U.S. population consumes less than half the recommended dietary allowance for zinc and are at increased risk for zinc deficiency. Zinc is known to be an essential component of DNA-binding proteins with zinc fingers, as well as copper/zinc superoxide dismutase and several proteins involved in DNA repair. Thus, zinc plays an important role in transcription factor function, antioxidant defense and DNA repair. Dietary deficiencies in zinc can contribute to single- and double-strand DNA breaks and oxidative modifications to DNA that increase risk for cancer development. This review will focus on potential mechanisms by which zinc deficiency impairs host protective mechanisms designed to protect against DNA damage, enhances susceptibility to DNA-damaging agents and ultimately increases risk for cancer.

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Author and article information

Contributors

Meral Miraloglu: +90 322 3386060 , miray70@gmail.com

Ergul Belge Kurutas: ergulkurutas@gmail.com

Perihan Ozturk: drperihanozturk@hotmail.com

Ozer Arican: ozerari@gmail.com

Journal

Journal ID (nlm-ta): Biol Proced Online

Journal ID (iso-abbrev): Biol Proced Online

Title: Biological Procedures Online

Publisher: BioMed Central (London )

ISSN (Print): 1480-9222

ISSN (Electronic): 1480-9222

Publication date (Electronic): 5 January 2016

Publication date PMC-release: 5 January 2016

Publication date Collection: 2016

Volume: 18

Electronic Location Identifier: 1

Affiliations

[ ]Department of Microbiology, Faculty of Medicine, Cukurova University, 01330 Adana, Turkey

[ ]Department of Biochemistry, Sutcu Imam University, Faculty of Medicine, Kahramanmaras, Turkey

[ ]Department of Dermatology, Sutcu Imam University, Faculty of Medicine, Kahramanmaras, Turkey

[ ]Department of Dermatology, Fatih University, Faculty of Medicine, Istanbul, Turkey

Article

Publisher ID: 30

DOI: 10.1186/s12575-015-0030-x

PMC ID: 4702401

PubMed ID: 26740800

SO-VID: 26353911-90ab-4b93-b2c1-45d39e48f027

License:

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

History

Date received : 4 October 2015

Date accepted : 23 December 2015

Custom metadata

ScienceOpen disciplines: Life sciences

Keywords: 8-iso-pgf2α,oxidative stress,trace elements,tinea pedis

Data availability:

ScienceOpen disciplines: Life sciences

Keywords: 8-iso-pgf2α, oxidative stress, trace elements, tinea pedis

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