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RNA-Seq: a revolutionary tool for transcriptomics.

Nature reviews. Genetics

Animals, Base Sequence, Chromosome Mapping, Exons, Gene Expression Profiling, methods, Humans, Models, Genetic, Molecular Sequence Data, RNA, analysis, Sequence Analysis, RNA, Transcription, Genetic

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      Abstract

      RNA-Seq is a recently developed approach to transcriptome profiling that uses deep-sequencing technologies. Studies using this method have already altered our view of the extent and complexity of eukaryotic transcriptomes. RNA-Seq also provides a far more precise measurement of levels of transcripts and their isoforms than other methods. This article describes the RNA-Seq approach, the challenges associated with its application, and the advances made so far in characterizing several eukaryote transcriptomes.

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      Journal
      19015660
      2949280
      10.1038/nrg2484

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