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      Neural Correlates of Emotion Regulation and Adolescent Suicidal Ideation

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          Abstract

          Background

          Research on the neural correlates associated with risk for suicidal ideation (SI) has been limited, particularly in one increasingly at risk group—adolescents. Previous research with adolescents indicates that poor emotion regulation skills are linked with SI, but these studies have not previously examined neural activation in service of emotion regulation between those with and without SI histories.

          Methods

          Here we examine whether SI is associated with neural responses during an emotion regulation fMRI task in a group of adolescents (N=49) ages 13 to 20 years old ( M = 16.95).

          Results

          While there were no differences between youth with and without SI in self-reported emotional responses to negative pictures, youth with SI activated the dorsolateral prefrontal cortex (dlPFC) more than youth without SI on trials where they attempted to regulate their emotional responses compared to trials where they passively viewed negative pictures. In contrast, during passive viewing of negative stimuli, youth with SI activated the dlPFC, temporoparietal junction, and cerebellum less than same age controls.

          Conclusions

          These findings were robust to controls for depression and adversity exposure and are consistent with the idea that youth with SI have disrupted emotion regulation, potentially related to differences in recruitment of top-down control regions. In contrast, youth without SI activated regions implicated in emotion regulation even when not directed to effortfully control their emotional response. This is the first study to examine neural function during emotion regulation as a potential neural correlate of risk for SI in adolescents.

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          Author and article information

          Contributors
          Journal
          101671285
          44575
          Biol Psychiatry Cogn Neurosci Neuroimaging
          Biol Psychiatry Cogn Neurosci Neuroimaging
          Biological psychiatry. Cognitive neuroscience and neuroimaging
          2451-9030
          7 September 2017
          07 September 2017
          February 2018
          01 February 2019
          : 3
          : 2
          : 125-132
          Affiliations
          University of North Carolina at Chapel Hill
          University of Washington
          Harvard Graduate School of Education
          Boston College School of Social Work
          University of Washington
          University of North Carolina at Chapel Hill
          Author notes
          Corresponding Author. Adam Bryant Miller, Department of Psychology and Neuroscience, The University of North Carolina at Chapel Hill. 235 E. Cameron Ave, CB #3270, Chapel Hill, NC, 27599. adam.miller@ 123456unc.edu , phone: 919-843-8150
          Article
          PMC5851479 PMC5851479 5851479 nihpa904816
          10.1016/j.bpsc.2017.08.008
          5851479
          29529407
          264e3922-ea5b-474e-a75f-785f2bbb41aa
          History
          Categories
          Article

          top down control,adolescent suicide,cognitive reappraisal,dlpfc,emotion regulation,suicidal ideation

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