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      Pandemic influenza preparedness: an ethical framework to guide decision-making

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      1 , , 2 , 3 , 4
      BMC Medical Ethics
      BioMed Central

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          Abstract

          Background

          Planning for the next pandemic influenza outbreak is underway in hospitals across the world. The global SARS experience has taught us that ethical frameworks to guide decision-making may help to reduce collateral damage and increase trust and solidarity within and between health care organisations. Good pandemic planning requires reflection on values because science alone cannot tell us how to prepare for a public health crisis.

          Discussion

          In this paper, we present an ethical framework for pandemic influenza planning. The ethical framework was developed with expertise from clinical, organisational and public health ethics and validated through a stakeholder engagement process. The ethical framework includes both substantive and procedural elements for ethical pandemic influenza planning. The incorporation of ethics into pandemic planning can be helped by senior hospital administrators sponsoring its use, by having stakeholders vet the framework, and by designing or identifying decision review processes. We discuss the merits and limits of an applied ethical framework for hospital decision-making, as well as the robustness of the framework.

          Summary

          The need for reflection on the ethical issues raised by the spectre of a pandemic influenza outbreak is great. Our efforts to address the normative aspects of pandemic planning in hospitals have generated interest from other hospitals and from the governmental sector. The framework will require re-evaluation and refinement and we hope that this paper will generate feedback on how to make it even more robust.

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          Most cited references42

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          Ethics and SARS: lessons from Toronto.

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            Accountability for reasonableness.

            N Daniels (2000)
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              Avian Influenza Virus Infections in Humans

              Seroepidemiologic and virologic studies since 1889 suggested that human influenza pandemics were caused by H1, H2, and H3 subtypes of influenza A viruses. If not for the 1997 avian A/H5N1 outbreak in Hong Kong of China, subtype H2 is the likely candidate for the next pandemic. However, unlike previous poultry outbreaks of highly pathogenic avian influenza due to H5 that were controlled by depopulation with or without vaccination, the presently circulating A/H5N1 genotype Z virus has since been spreading from Southern China to other parts of the world. Migratory birds and, less likely, bird trafficking are believed to be globalizing the avian influenza A/H5N1 epidemic in poultry. More than 200 human cases of avian influenza virus infection due to A/H5, A/H7, and A/H9 subtypes mainly as a result of poultry-to-human transmission have been reported with a > 50% case fatality rate for A/H5N1 infections. A mutant or reassortant virus capable of efficient human-to-human transmission could trigger another influenza pandemic. The recent isolation of this virus in extrapulmonary sites of human diseases suggests that the high fatality of this infection may be more than just the result of a cytokine storm triggered by the pulmonary disease. The emergence of resistance to adamantanes (amantadine and rimantadine) and recently oseltamivir while H5N1 vaccines are still at the developmental stage of phase I clinical trial are causes for grave concern. Moreover, the to-be pandemic strain may have little cross immunogenicity to the presently tested vaccine strain. The relative importance and usefulness of airborne, droplet, or contact precautions in infection control are still uncertain. Laboratory-acquired avian influenza H7N7 has been reported, and the laboratory strains of human influenza H2N2 could also be the cause of another pandemic. The control of this impending disaster requires more research in addition to national and international preparedness at various levels. The epidemiology, virology, clinical features, laboratory diagnosis, management, and hospital infection control measures are reviewed from a clinical perspective.
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                Author and article information

                Journal
                BMC Med Ethics
                BMC Medical Ethics
                BioMed Central (London )
                1472-6939
                2006
                4 December 2006
                : 7
                : 12
                Affiliations
                [1 ]Centre for Research on Inner City Health, St. Michael's Hospital, 30 Bond Street, Toronto, Ontario, M5B 1W8, Canada
                [2 ]Clinical Ethics Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada
                [3 ]Joint Centre for Bioethics, University of Toronto, Toronto, Ontario, M5G 1L4, Canada
                [4 ]Primary Care Research Unit, Sunnybrook Health Sciences Centre, and Joint Centre for Bioethics, Toronto, Ontario M5G 1L4, Canada
                Article
                1472-6939-7-12
                10.1186/1472-6939-7-12
                1698926
                17144926
                26602355-64af-4bdc-a488-a9dae8fd37b4
                Copyright © 2006 Thompson et al; licensee BioMed Central Ltd.

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 13 November 2005
                : 4 December 2006
                Categories
                Debate

                Medicine
                Medicine

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