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      Assessment of Periprostatic and Subcutaneous Adipose Tissue Lipolysis and Adipocyte Size from Men with Localized Prostate Cancer

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          Abstract

          The prostate is surrounded by periprostatic adipose tissue (PPAT), the thickness of which has been associated with more aggressive prostate cancer (PCa). There are limited data regarding the functional characteristics of PPAT, how it compares to subcutaneous adipose tissue (SAT), and whether in a setting of localized PCa, these traits are altered by obesity or disease aggressiveness. PPAT and SAT were collected from 60 men (age: 42–78 years, BMI: 21.3–35.6 kg/m 2) undergoing total prostatectomy for PCa. Compared to SAT, adipocytes in PPAT were smaller, had the same basal rates of fatty acid release (lipolysis) yet released less polyunsaturated fatty acid species, and were more sensitive to isoproterenol-stimulated lipolysis. Basal lipolysis of PPAT was increased in men diagnosed with less aggressive PCa (Gleason score (GS) ≤ 3 + 4) compared to men with more aggressive PCa (GS ≥ 4 + 3) but no other measured adipocyte parameters related to PCa aggressiveness. Likewise, there was no difference in PPAT lipid biology between lean and obese men. In conclusion, lipid biological features of PPAT do differ from SAT; however, we did not observe any meaningful difference in ex vivo PPAT biology that is associated with PCa aggressiveness or obesity. As such, our findings do not support a relationship between altered PCa behavior in obese men and the metabolic reprogramming of PPAT.

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                Author and article information

                Journal
                Cancers (Basel)
                Cancers (Basel)
                cancers
                Cancers
                MDPI
                2072-6694
                28 May 2020
                June 2020
                : 12
                : 6
                : 1385
                Affiliations
                [1 ]Discipline of Physiology, School of Medical Sciences, Charles Perkins Centre, Faculty of Medicine and Health, The University of Sydney, New South Wales 2006, Australia; dmil3834@ 123456uni.sydney.edu.au
                [2 ]Cancer Division, The Kinghorn Cancer Centre/Garvan Institute of Medical Research, New South Wales 2010, Australia; t.cusick@ 123456garvan.org.au (T.C.); kate.mahon@ 123456lh.org.au (K.L.M.); a.haynes@ 123456garvan.org.au (A.-M.H.); pstricker@ 123456stvincents.com.au (P.D.S.); lisa.horvath@ 123456lh.org.au (L.G.H.)
                [3 ]Discipline of Medicine, Central Clinical School, The University of Sydney School of Medicine, Faculty of Medicine and Health, The University of Sydney, New South Wales 2006, Australia
                [4 ]Department of Medical Oncology, Chris O’Brien Lifehouse, New South Wales 2050, Australia
                [5 ]Royal Prince Alfred Hospital, New South Wales 2050, Australia
                [6 ]School of Medicine, Lipid Research Centre, Molecular Horizons, University of Wollongong, New South Wales 2522, Australia; colinc@ 123456uow.edu.au (C.H.C.); bmeyer@ 123456uow.edu.au (B.J.M.)
                [7 ]Illawarra Medical Research Institute, University of Wollongong, New South Wales 2522, Australia
                [8 ]St. Vincent’s Clinical School, The University of New South Wales, New South Wales 2010, Australia
                [9 ]St. Vincent’s Prostate Cancer Centre, St. Vincent’s Clinic, New South Wales 2010, Australia
                [10 ]South Australian Health and Medical Research Institute, South Australia 5000, Australia; gary.wittert@ 123456adelaide.edu.au (G.A.W.); lisa.butler@ 123456adelaide.edu.au (L.M.B.)
                [11 ]School of Medicine and Freemasons Foundation Centre for Men’s Health, University of Adelaide, South Australia 5000, Australia
                Author notes
                Author information
                https://orcid.org/0000-0001-7962-7890
                https://orcid.org/0000-0003-2698-3220
                https://orcid.org/0000-0003-3922-1137
                Article
                cancers-12-01385
                10.3390/cancers12061385
                7352157
                32481537
                268d39e6-119a-4dbd-87bc-b5c95f11c3b8
                © 2020 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 25 April 2020
                : 27 May 2020
                Categories
                Article

                prostate cancer,periprostatic adipose tissue,lipolysis,localized prostate cancer,subcutaneous adipose tissue

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