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      Importance of Retrograde Coronary Flow in the Prediction of Experimental Myocardial Infarct Size

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          Abstract

          The relationship between myocardial infarct size (measured by a histochemical stain) and coronary collateral blood flow (measured via retrograde flow and by use of radioactive microspheres) was studied in anesthetized dogs with high, moderate and low retrograde flows undergoing a 2-hour occlusion and 30-min reperfusion of the left anterior descending coronary artery. The results demonstrate that experimental myocardial infarct size is closely related to native coronary collateral blood flow, and the large variability in collateral perfusion amongst dogs is a source of variability in the mass of myocardium undergoing irreversible damage following acute coronary occlusion. Results also demonstrate that the variability in experimental infarct size can be reduced and ultimate infarct size predicted prior to irreversible tissue injury by initial measurement of retrograde coronary blood flow.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1986
          1986
          11 November 2008
          : 73
          : 6
          : 333-346
          Affiliations
          Departments of Pharmacology and Toxicology and Medicine, Cardiology Section. Medical College of Wisconsin, Milwaukee, Wisc, USA
          Article
          174027 Cardiology 1986;73:333–346
          10.1159/000174027
          3791333
          © 1986 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 14
          Categories
          Original Paper

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